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Neurokinins (NK), a family of 9-11 amino acid peptides, trigger a variety of inflammatory responses. 1,2 The most well characterized neurokinins, namely substance P, NKA, and NKB, are involved in a variety of responses including pain transmission, neurogenic inflammation, bronchoconstriction, and vasodilation. The peptides act

Structure of Sch 218157, a Cyclodepsipeptide with NeurokininActivity.--(CHU, M.; CHAN, T. M.; DAS, P.; MIERZWA, R.; PATEL, M.; PUAR, M. S.; J. Antibiot. 53 (2000) 7, 736-738; Schering-Plough Res. Inst., Kenilworth, NJ 07033, USA; EN)

Neurokinins (NKs), also known as tachykinins (TKs), are members of a family of 9-ll amino acid peptides which are involved in various pathological conditions including inflammation1'2), pain transmission, cancer,