Modern standards of laboratory animal Science include wor�ing with laboratory animals of high quality�� in �articular�� with s�ecific �athogen free (SPf� mice and rats. on the other hand�� assisted re�roductive technologies (arT� are widely used in modern medicine for human infertility treatment as well as for genome resource ban�ing. in the �resent study�� a com�arison of body weight�� blood �ressure (BP� and behavior in the «elevated �lus maze» (EPM� test was made between three grou�s of iSiaH (inherited stress induced arterial hy�ertension� rats�� a grou� of animals that were born and raised in a conventional animal facility and two grou�s from an SPf animal facility (one with animals born naturally and another with animals resulting from arT�. There were no changes in BP between the grou�s�� but the behavior of iSiaH differed de�ending on rearing conditions. in �articular�� grooming time�� as well as the number of defecations and the number of urinations during the test were decreased in both grou�s of iSiaH rats born in the SPf animal facility as com�ared to iSiaH rats born in the conventional animal facility. The behavior of the iSiaH rat offs�ring resulting from arT was different from that of the naturally born grou��� the EPM test revealed reduced anxiety in the former. The results of the �resent study indicate that the rearing conditions as well as re�roductive technologies affect some behavioral characteristics in adult iSiaH rats�� although they develo� arterial hy�ertension in all the conditions used in this study.Key words�� iSiaH rats; blood �ressure; assisted re�roductive technologies; behavior.Современные стандарты в исследованиях на ла�ораторных животных направлены на то�� �то�ы ра�отат�� с ла�ораторными животными высокого ка�ества�� в �астности со сво�одными от специфи�еских патогенов (SPf� мышами и крысами. С другой стороны�� вспомогател��ные репродуктивные технологии (ВРт� широко испол��зу�тся в современной медицине для ле�ения �есплодия �еловека�� а также для создания крио�анков генети�е-ских ресурсов. В данной ра�оте проведено сравнение массы тела�� артериал��ного давления (�Д� и поведения в тесте «приподнятый крестоо�разный ла�иринт» (���л� трех групп крыс линии НИС�Г (наследственная индуцированная стрессом артериал��ная гипертензия��� группа крыс�� рожденных и выращенных в конвен-ционал��ном виварии�� и двух групп из SPf-вивария (рожденных естественным путем и полу�енных путем применения репродук-тивных технологий�. Разли�ий по вели�ине �Д между исследуе-мыми группами о�наружено не �ыло�� но выявлены разли�ия в поведении крыс линии НИС�Г при разных условиях содержания. Время груминга�� а также �исло актов дефекации и уринации за время теста �ыло достоверно ниже у крыс о�еих групп�� родив-шихся в условиях SPf-вивария�� по сравнени� с крысами�� рожден-ными в условиях конвенционал��ного вивария. �оведение крыс линии НИС�Г�� рожденных при помощи ВРт�� отли�алос�� от поведения крыс линии НИС�Г�� рожденных естественным путем. тест ���л выявил снижение тревожности у первых. Резул��таты данного и...
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