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The purpose of this study was to determine if prostaglandins regulate alterations in muscle nutritive blood flow response to short‐term exercise training in young and aged individuals. Local thigh muscle nutritive flow and 6‐keto‐prostaglandin F1α (PGF1α) were monitored using microdialysis. Dialysate samples were collected continuously during acute exercise before and after 7 days of exercise training from 27 healthy subjects (6 young men (YM), 8 young women (YW), 7 aged men (AM), and 6 aged women (AW)). The exercise regimen consisted of 7 consecutive days of training for 1hr/day at 70% VO2peak. PGF1α content was higher during exercise after, compared to before, training in YM (43.6 ± 1.9 vs. 36.4 ± 1.3 pg/ml, respectively; P<.05) without a significant difference in nutritive flow. PGF1α content and nutritive flow during exercise was not changed in response to exercise training in YW, AW, and AM. There was a higher PGF1α content during exercise in YM than in YW and AM after training (43.6 ± 1.9 vs. 35.7 ± 1.1 and 33.6 ± 0.7 pg/ml, respectively; P<.05), but there were no differences in nutritive flow between these groups. These data demonstrate that PGF1α response to acute exercise increases with training in YM, and suggest changes in exercise‐induced PGF1α with training may not result in training‐induced alterations in muscle nutritive blood flow response to acute exercise.NIH AG‐19209 (Hickner); MD Choi supported by EAS

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