Background: Hypertension in pregnancy is a global problem and complicates approximately 10-17% of pregnancies. The incidence of PIH in India ranges from 5% to 15%. Uric acid is a marker of oxidative stress, tissue injury and renal dysfunction and therefore might be helpful in the prediction of complications of PE. Literature on serum uric acid as a predictor of complications of PE is conflicting. The present is intended to study uric acid as an important biomarker in hypertension in pregnancy. Methods: This was prospective observational analytical case control study of 180 individuals done at JSS Hospital, Mysore, India from January 2015 to July 2016. Results: A positive correlation was observed between rise in uric acid and severity of hypertension in pregnancy (p <0.01). Hypertensive mothers with uric acid levels >6.0mg/dl shows 100% maternal deaths, 79.4% with eclampsia and 71.9% with preterm delivery. Conclusions: A positive correlation was observed between rise in uric acid and severity of hypertension in pregnancy. Hyperuricemia in patients with hypertensive disorders of pregnancy is a strong risk factor for several maternal and perinatal complications.

To compare the biochemical and haematological markers in pre¬ eclampsia and eclampsia patients with normal pregnancies. Standard antenatal follow up should be carried out for the early detection and prevention of PIH. Tests like serum LDH, uric acid and alkaline phosphatase could help to predict and to deal with the adverse complications of PIH, which are considered as cost effective as these tests are routinely done in most of the laboratories. The fact that hypertension in pregnancy is largely a preventable condition is established by observing the negligible incidence of pre eclampsia and eclampsia with the institution of early management. In present study, we observed a specific pattern of disease and its related variation with these markers. Simple markers like LDH, Uric acid, Platelet count, Alkaline phosphatase, PTT and aPTT are the early predictors of the maternal and fetal outcome .The early detection of compromised status combined with the institution of prompt treatment has been proven to have a crucial and definite role in reducing the morbidity and mortality of both mother and fetus.

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