Lichen planus pemphigoides (LPP) is a rare autoimmune bullous disorder that is rarer in children characterized by bullae on lichen planus like papules and the normal looking skin. Clinical, histopathological and direct immunoflourescence evaluation is important for the diagnosis of this entity. We report a case of LPP in a 5-year-old girl child probably triggered by an episode of preceding varicella. Diagnosis was confirmed by histopathology and immunofluorescence examination. Histological findings were typical of lichen planus from the biopsy taken from a violaceous to erythematous papule and characteristic of bullous pemphigoid in the biopsy taken from a bullous lesion with evidence of immunoglobulin G and C3 deposition along the basement membrane zone on direct immunofluorescence.

Diabetic complications are generally classified into macrovascular and microvascular conditions. Depending on the location of the atherosclerotic lesion, macrovascular disease (coronary artery disease, cerebrovascular disease, peripheral vascular disease) may occur. The prevalence of diabetes and its complication is increasing all over the world, particularly in developing countries. It has emerged as a major public health problem in our country. The disease Madhumeha is described under Prameha and it is the subtype of Vataja Prameha Madhumeha manifest due to morbidity of Shukra and Shonita which is incurable. In Madhumeha, Sara is the most useful entity for the measurement of strength and the life span of an individual, so it’s very important to know about Sara from a treatment point of view because lean and thin persons may have Pravara Sara. Here the attempt will be made to highlight the study for the assessment of the macrovascular complication of Madhumeha and its association with Sara. This study has been done on the basis of subjective and objective parameters in T2DM patients with macrovascular complications. Sara was assessed in each subject as per the scheduled proforma. In the research, we found that the diabetic complications were related to Sara, which is statistically highly significant. The conclusion of the study is Avara Meda Sara patients were found with all types of complications, only a few patients with complications belong to Madhyama Meda Sara, and there are no patients belonging to Pravara Meda Sara. Maximum patients of T2DM complication of Asthi, Majja and Shukra Sara having Madhyama Sara.

BACKGROUND: Alopecia areata is an autoimmune condition with a worldwide occurrence. It usually presents as patchy, non-scarring hair loss. There is a paucity of clinical data in Indians. OBJECTIVES: To study the clinical profile and to know the association with various systemic and dermatological disorders. METHODS: A descriptive study was conducted on 100 cases of alopecia areata after taking informed consent, over a period of 16 months from December 2012 to April 2014. A detailed history of the patient regarding associated systemic and dermatological disorders and various autoimmune disorders were documented, relevant investigations were done. RESULTS: Incidence of alopecia areata in patients attending dermatology out-patient department was 1.7%. There was slight male preponderance (51%). Most common age group involved was 20-40yrs. (47%). Alopecia areata was higher among low socioeconomic group (62%). Recurrences of AA was noted in 14% of cases. Stress acting as triggering factor in 12%. Pregnancy and postpartum accounted for 4% of cases. Atopic dermatitis was noted in 1%, seborrheic dermatitis was noted in 1%, lichen planus was noted in 2%, psoriasis noted in 1% cases. Average age of onset of alopecia areata in atopics was 7.9 years. Occiput was the most common site accounting for 39.3% of cases. Nail pitting was noted in 7% of cases. In 2 cases 20 nail dystrophy was noted. Patchy type was the most common type of alopecia seen in 73% of patients. As per IKEDAS classification -71% cases belonged to common type, 18% to atopic type, 5% to pre hypertensive, 6% to autoimmune type. Bronchial asthma was noted in 3%, Diabetes mellitus in 5%, hypothyroidism noted in 12% of cases.

Pyoderma gangrenosum is a rare, non-infectious, immune mediated, neutrophilic dermatosis associated with underlying systemic disease in 50% of cases. Brocq first described pyoderma gangrenosum in 1916.It is common in fourth and fifth decade. But childhood PG, reported was 4% percent. PG has been associated with systemic disorders like inflammatory bowel disease, arthritis, haematological disorders, autoimmune diseases, solid organ tumors, drugs etc. First line of management for PG is oral corticosteroids, dapsone and other sulphones. Other immunosuppresants are used as second line of treatment. Here we report a case of childhood PG not responding to conventional treatment but responded to methylprednisolone pulse therapy.