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Angiomyolipomas are benign mesenchymal neoplasms, presenting with a variable mixture of adipose tissue, smooth muscle and vascular component. Although they are typically found in the kidneys, many cases of extrarenal angiomyolipomas have been reported. They are extremely rarely present in the uterus. We describe a case of a 56-year-old woman, operated on for leiomyoma. Total laparohysterectomy and bilateral adnexectomy was performed. After histological and immunohistochemical examination, the final diagnosis of uterine angiomyolipoma was made. Renal and extrarenal angiomyolipomas are compared in regard to clinical and morphological aspect and their difference from PEComas is dicussed. PEComas have been defined during the last decade and there are still issues regarding terminological clarity and overlapping.

The relation between systemic autoimmune diseases that affect women in their reproductive age and the neoplasms of the lower genital tract caused by high-risk HPV strains are studied in many investigations. The studies have been focused mainly on patients with systemic lupus erythematosus exposed to glucocorticoids and immunosuppressive therapy. A higher risk of HPV infection persistence and premalignant and malignant cervical lesions formation is found among them. There are similar, though scantier data about other systemic rheumatic diseases – rheumatoid arthritis, Sjögren‘s syndrome, and systemic sclerosis. Presumably, this fact is determined by specific features of autoimmune inflammation and the impact of immunosuppressive treatment. It contributes to human papilloviruses persistence and their integration into cervical cells. HPV vaccines use in these patients have proved to be safe and effective, and is an object of special interest.

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