No abstract

Abstract. Chiral (enantiomerically pure) hydrogen thiophosphoramidates and hydrogen phosphoramidates and their phosphinamide analogs derived from norephedrine and other chiral (enantiomerically pure) amino alcohols catalyze the enantioselective addition of dialkylzincs to aldehydes. The presence of titanium tetraisopropoxide increases the enantioselectivity, providing enantiomerically enriched secondary alcohols with up to 98% ee. The enantioselectivities of thiophosphoramidates and thiophosphinamides are higher than those of the oxygen analogs. The phosphoramidates and thiophosphoramidates, without the hydroxyl group, also catalyze the addition of dialkylzinc to aldehydes in the absence of Ti(O'Pr),.

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ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.