A linear route for the preparation of chromeno-thio/furopyridine system as potential analogs for anticancer compound lamellarin D is reported in this paper. The target molecules were obtained in modest to good yields by using FeCl 3 catalyzed modified Pictet-Spengler reaction as the crucial final step. Compounds bearing furan rings showed higher overall yield compared to their thiophene congeners. Final molecules were subjected to anticancer activity screening against three different cancer cell lines. Compounds bearing fused furan rings showed better activity, with the best IC 50 value (6.83 μM) obtained when 4-(4-methoxyphenyl)-6H-chromeno[3,4-b]furo [3,2-d]pyridin-6-one was screened against MCF-7 (breast cancer) cell lines.[a] T.

FeCl 3 catalyzed synthesis of chromeno [4,3-b]pyrrolo[3,2-h]quinolin-7(1H)-one compounds is reported in this paper. The target molecules were synthesized by combining 4-hydroxy coumarin, 7-amino indole and diverse aromatic aldehydes in 1,4-dioxane as a solvent, at 90 8C. The final compounds obtained were subjected to anticancer activity evaluation using murine melanoma cell lines (B16F10). Best result was obtained for compound bearing 2-chloro-3-pyridyl substituent, which showed IC 50 value of 70.74 mM.

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