This research is motivated at this time a lot of product advertisements placed in a soap opera. The test of this study is to determine the effect of product placement on consumer buying interest and brand awareness as a mediating variable. The sample in this study was 100 respondents loyal viewers of the soap opera holy SCTV in the village of Kauman Ngoro Jombang. The instruments in this study used a questionnaire and were analyzed using SEM-PLS analysis. The results of this study indicate that product placement can significantly influence consumer purchase interest and brand awareness is a partial mediator between product placement and buying interest of CintaSuci soap opera audience on SCTV.