Under conditions of omeprazole-induced hypergastrinemia the activity of NOS and the concentration of NO 2 , the end product of metabolism of nitric oxide were studied in salivary glands of rats. We detected an increase in NOS activity, reaching a maximum (7,61±0,39 ìmol [NO 2 ]/(g*min) at 14th day of the experiment. At 28th day following omeprazole introduction its activity was 5,76±0,25 ìmol [NO 2 ]/(g*min).
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