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Background:Osteoporosis is a widespread health concern associated with an increased risk of fractures in individuals with low bone mineral density (BMD). Dual-energy x-ray absorptiometry (DXA) is the gold standard to measure BMD, but methods based on the assessment of plain films, such as the digital radiogrammetry,1are also available. We describe a novel approach based on the assessment of hip texture with deep learning to estimate BMD.Objectives:To compare the BMD estimated by assessing hip texture using a deep learning model and that measured by DXA.Methods:In this study, we identified 1,203 patients who underwent DXA of left hip and hip plain film within six months. The dataset was split into a training set with 1,024 patients and a testing set with 179 patients. Hip images were obtained and regions of interest (ROI) around left hips were segmented using a tool based on the curve Graph Convolutional Network. The ROIs are processed using a Deep Texture Encoding Network (Deep-TEN) model,2which comprises the first 3 blocks of Residual Network with 18 layers (ResNet-18) model followed by a dictionary encoding operator (Figure 1). The encoded features are processed using a fully connected layer to estimate BMD. Five-fold cross-validation was conducted. Pearson’s correlation coefficient was used to assess the correlation between predicted and reference BMD. We also test the performance of the model to identify osteoporosis (T-score ≤ -2.5)Figure 1.Schematic representation of deep learning models to extract and encode texture features for estimation of hip bone density.Results:We included 151 women and 18 men in the testing dataset (mean age, 66.1 ± 1.7 years). The mean predicted BMD was 0.724 g/cm2compared with the mean BMD measured by DXA of 0.725 g/cm2(p = 0.51). Pearson’s correlation coefficient between predicted and true BMD was 0.88. The performance of the model to detect osteoporosis/osteopenia was shown in Table 1. The positive predictive value was 87.46% for a T-score ≤ -1 and 83.3% for a T-score ≤ -2.5. Furthermore, the mean FRAX® 10-year major fracture risk did not differ significantly between scores based on predicted (6.86%) and measured BMD (7.67%, p=0.52). The 10-year probability of hip fracture was lower in the predicted score (1.79%) than the measured score (2.43%, p = 0.01).Table 1.Performance matrices of the deep texture model to detect osteoporosis/osteopeniaT-score ≤ -1T-score ≤ -2.5Sensitivity91.11%(95% CI, 83.23% to 96.08%)33.33%(95% CI, 17.29% to 52.81%)Specificity86.08%(95% CI, 76.45% to 92.84%)98.56%(95% CI, 94.90% to 99.83%)Positive predictive value88.17%(95% CI, 81.10% to 92.83%)83.33%(95% CI, 53.58% to 95.59%)Negative predictive value89.47%(95% CI, 81.35% to 94.31%)87.26%(95% CI, 84.16% to 89.83%)Conclusion:This study demonstrates the potential of the bone texture model to detect osteoporosis and to predict the FRAX score using plain hip radiographs.References:[1]Zandieh S, Haller J, Bernt R, et al. Fractal analysis of subchondral bone changes of the hand in rheumatoid arthritis. Medicine (Baltimore) 2017;96(11):e6344.[2]Zhang H, Xue J, Dana K. Deep TEN: Texture Encoding Network. The IEEE Conference on Computer Vision and Pattern Recognition (CVPR) 2017:708-17.Disclosure of Interests:None declared

Background:Osteoarthritis is a degenerative disorder characterized by radiographic features of asymmetric loss of joint space, subchondral sclerosis, and osteophyte formation. Conventional plain films are essential to detect structural changes in osteoarthritis. Recent evidence suggests that fractal- and entropy-based bone texture parameters may improve the prediction of radiographic osteoarthritis.1In contrast to the fixed texture features, deep learning models allow the comprehensive texture feature extraction and recognition relevant to osteoarthritis.Objectives:To assess the predictive value of deep learning-extracted bone texture features in the detection of radiographic osteoarthritis.Methods:We used data from the Osteoarthritis Initiative, which is a longitudinal study with 4,796 patients followed up and assessed for osteoarthritis. We used a training set of 25,978 images from 3,086 patients to develop the textual model. We use the BoneFinder software2to do the segmentation of distal femur and proximal tibia. We used the Deep Texture Encoding Network (Deep-TEN)3to encode the bone texture features into a vector, which is fed to a 5-way linear classifier for Kellgren and Lawrence grading for osteoarthritis classification. We also developed a Residual Network with 18 layers (ResNet18) for comparison since it deals with contours as well. Spearman’s correlation coefficient was used to assess the correlation between predicted and reference KL grades. We also test the performance of the model to identify osteoarthritis (KL grade≥2).Results:We obtained 6,490 knee radiographs from 446 female and 326 male patients who were not in the training sets to validate the performance of the models. The distribution of the KL grades in the training and testing sets were shown in Table 1. The Spearman’s correlation coefficient was 0.60 for the Deep-TEN and 0.67 for the ResNet18 model. Table 2 shows the performance of the models to detect osteoarthritis. The positive predictive value for Deep-TEN and ResNet18 model classification for OA was 81.37% and 87.46%, respectively.Table 1Distribution of KL grades in the training and testing sets.KL grades01234TotalTraining set1089341.9%458218.7%611423.5%332012.8%7993.1%25,978Testing set247238.1%135320.8%169626.1%77511.9%1943.0%6,490Table 2Performance matrices of the Deep-Ten and ResNet18 models to detect osteoarthritisDeep-TENResNet18Sensitivity62.29%(95% CI, 60.42%–64.13%)59.14%(95% CI, 57.24%–61.01%)Specificity90.07%(95% CI, 89.07%–91.00%)94.09%(95% CI, 93.30%–94.82%)Positive predictive value81.37%(95% CI, 79.81%–82.84%)87.46%(95% CI, 85.96%–88.82%)Negative predictive value77.42%(95% CI, 77.64%–79.65%)76.77%(95% CI, 75.93%–77.59%)Conclusion:This study demonstrates that the bone texture model performs reasonably well to detect radiographic osteoarthritis with a similar performance to the bone contour model.References:[1]Bertalan Z, Ljuhar R, Norman B, et al. Combining fractal- and entropy-based bone texture analysis for the prediction of osteoarthritis: data from the multicenter osteoarthritis study (MOST). Osteoarthritis Cartilage 2018;26:S49.[2]Lindner C, Wang CW, Huang CT, et al. Fully Automatic System for Accurate Localisation and Analysis of Cephalometric Landmarks in Lateral Cephalograms. Sci Rep 2016;6:33581.[3]Zhang H, Xue J, Dana K. Deep TEN: Texture Encoding Network. The IEEE Conference on Computer Vision and Pattern Recognition (CVPR) 2017:708-17.Disclosure of Interests:None declared