Background: Ticks and tick-borne diseases (TBDs) are considered to be the most serious health problems for animals and humans. This issue prompts veterinarians and researchers to adopt better preventive and control strategies. Therefore, this study aims to develop hybridoma vaccine against Hylomma dromedarii infesting Camelus dromedaries. Methods: Myeloma cell culture was administered to the immunized mouse in order to produce hybridomas cells. These cells were then emulsified with Montanide ISA-51 adjuvant. Two doses of the prepared anti-tick vaccine were administered intradermally to camels with an interval of five weeks. The humoral response of experimental animals was measured by indirect enzyme-linked immunosorbent assay (ELISA). Result: There was a significant (p less than 0.05) decrease in immune responses in tick counts and molting capacity. Overall, 85% efficacy of the developed vaccine was recorded. It is concluded that hybridoma based vaccine is effective in controlling H. dromedarii infestation against camels.

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