Background
Food allergy has emerged as a significant medical problem in the last decades. Probiotics' effects on food allergies have brought contradictory results. The present study aimed to assess the probiotic's results in cytokines related to food allergy through meta-analysis.
Methods
Science Direct and Scopus search engines were searched for relevant studies published from 2008 to 2019 without language exclusion. Some experiments were selected from articles evaluating the effect of probiotics on food allergy through pre-clinical studies, with the results published in peer-reviewed journals, with any dispersion measure. Cytokines values were selected as outcomes. We used metaregression to study the probiotic effect in each cytokine and the influence of some experimental design factors.
Results
We obtained a total of 13 studies that met the criteria for the meta-analysis. Probiotics download the regulation of IL-4 and IgE and the upload regulation in IL-6 and TGF-β compared to controls. Lactobacillus is a species that helps in the restoration of IL-4 levels. Animal age, probiotic concentration, and microorganism specie affect the probiotic effect in INF-γ.
Conclusion
The meta-analysis evidenced, in pre-clinical studies, the effects of probiotics on cytokines related to food allergy.
Se evalúo la calidad e indicadores de eficiencia tecnológica de la producción del queso semiduro Gouda en la Fábrica de Quesos Sibanicú, para la determinación de las mejores condiciones operacionales que permitan una adecuada conservación. Se determinan las características químico-físicas de la leche, el suero y los quesos a la salida de prensa y al final de la maduración. Se determinan el rendimiento, aprovechamiento de los componentes y las mermas como indicadores de eficiencia tecnológica. Se realiza una evaluación sensorial a los 20, 30 y 40 días de maduración. La leche presenta una calidad químico-física aceptable debido a un contenido inferior a lo normado de sólidos no grasos. Los quesos cumplen con los parámetros tecnológicos establecidos, se alcanza la mayor calificación a los 30 días de maduración obteniéndose buenos rendimientos. Los índices de consumo resultan menores que los del queso Patagrás y las mermas son equivalentes a valores de referencia.
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