Background: Hypertensive disorders of pregnancy complicate about 8% of all gestations. Hypertensive disorders are responsible for significant maternal and perinatal morbidity and mortality. AIMS: To determine the hematological parameters and morbidity in neonates born to mothers with gestational hypertension, pre-eclampsia or eclampsia syndrome and in neonates born to normotensive mothers without any maternal complications or medical illness with special reference to platelet count and neutrophil count. Methods and Material: The study was a prospective study conducted on neonates born to pregnant women complicated with gestational hypertension, pre-eclampsia or eclampsia syndrome and neonates born to normotensive mothers recruited at Neonatal Intensive Care Unit and Post natal wards who were delivered at Ananta Hospital and AIMS & RC, Rajsamand (Raj.) from October 2018 to September 2019 and the hematological parameters of these babies were studied. Results: In our study we observed that the mean value of platelet count were significantly lower in study group compared to control group which was highly Statistical significant (p<0.001). The mean value of PT, aPTT, Bleeding Time and Clotting time were significantly higher in study group, as compared to control group. The statistical analytic differences were highly significant in all parameters i.e. PT, aPTT, Bleeding Time and Clotting time (P<0.001). Conclusion: To conclude early hematological screening of babies are recommended to facilitate early detection and management of serious neonatal complications describes above, to decrease morbidity and improved growth, development and survival. Keywords: Pre-eclampsia, Eclampsia, Gestational Hypertension, Newborns.
Background: Beta-thalassemia major (β-TM), is a type of chronic, microcytic anaemia that is characterized by impaired biosynthesis of the β-globin chain leading to accumulation of unpaired α-globin chain. Due to the severe anaemia caused in Thallassemia, patient must undergo repeated blood transfusions for survival. Repeated blood transfusions lead to built-up of iron overload which is responsible for tissue deposition of excess iron, ultimately resulting in iron toxicity. There are evidences of aminoaciduria, hypercalciuria, phosphaturia, magnesiuria, hyperuricosuria, low urine osmolality, and excess urinary secretion of markers of tubular damage such as N-acetyl-D-glucosaminidase in patients with beta-thalassemia major. In the present study, authors tried to investigate the proportion of patients diagnosed with β-Thalassemia Major manifesting renal dysfunction and electrolyte imbalance. Material and Methods: It was a hospital based case-control study involving 100 patients coming to Department of Pediatric Medicine, and belonging to the age group 1 to 18 years. Equal number of healthy age and sex matched children were taken as controls. Results: When cases and controls were compared with respect to albuminuria, blood pH, serum bicarbonate, phosphorus and blood urea, higher number of cases had deranged values as compared to the healthy controls [p<0.05]. Conclusion: Renal damage and tubular dysfunctions leading to eletrolyte imbalances exist in children with β-thalassemia major. Keywords: kidney, Thalassemia, Electrolytes, children.
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