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ABSTRACT-The efficacy of NKH477, a novel water-soluble forskolin derivative, in improving cardiac failure was assessed in dog heart-lung preparations. Cardiac func tions depressed by pentobarbital, propranolol or verapamil so that cardiac output had been reduced by about 40-50% of the respective control were all improved by NKH477 (10-100/dg) in a dose-dependent manner. With 100 ,ug NKH477, almost complete restoration of cardiac performance was attained in the respective cardiac fail ures. In the combination of NKH477 with ouabain (30,ug), 30,ug of NKH477 com pletely restored the cardiac function depressed by pentobarbital, associated with a slight but not significant increase in heart rate. No arrhythmias were induced by any of the NKH477 doses used in the experiments. These results suggest that NKH477 should be subjected to clinical trials in the treatment of cardiac failure.

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