Thiophene derivatives with multiple substitutions are prepared from vinylidene bromide, which is synthesized by the reaction of thiophene-2-carboxaldehyde with carbon tetrabromide in the presence of PPh 3 , as a core molecule through several coupling reactions such as Suzuki-Miyaura coupling and palladium-catalyzed CH arylation. The reactions with a wide variety of organic halides lead to a series of substituted thiophene derivatives in moderate to good yields.

No abstract

No abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

Benzothiazole derivatives R 0270Use of NaOH as a New Activator for the Palladium-Catalyzed Direct CH Arylation of Thiazole Derivatives. -(MIYAOKU, T.; MORI*, A.; Heterocycles 77 (2009) 1, 151-155; Dep. Chem. Sci. Eng., Fac. Eng., Kobe Univ., Nada, Kobe 657, Japan; Eng.) -C. Cyrus 22-126