Homogeneous chiral nickel-bisphosphine complexes catalyze the asymmetric hydrogenation of alpha-amino-beta-keto ester hydrochlorides through dynamic kinetic resolution to efficiently afford anti-beta-hydroxy-alpha-amino esters with high diastereo- and enantioselectivities.

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Aminocarboxylic acids (hydrazinocarboxylic acids) and esters Q 0440 Rhodium-Catalyzed Asymmetric Hydrogenation Through Dynamic Kinetic Resolution: Asymmetric Synthesis of anti-β-Hydroxy-α-amino AcidEsters. -(MAKINO, K.; FUJII, T.; HAMADA*, Y.; Tetrahedron: Asymmetry 17 (2006) 4, 481-485; Grad. Sch. Pharm. Sci., Chiba Univ., Inage, Chiba 263, Japan; Eng.) -Nuesgen 31-079

Hydrogenation O 0220Catalytic Asymmetric Hydrogenation of α-Amino-β-keto Ester Hydrochlorides Using Homogeneous Chiral Nickel-Bisphosphine Complexes Through DKR. -The asymmetric hydrogenation using homogeneous chiral Nickel-bisphosphine complexes is superior to the iridium-catalyzed process regarding the substrate generality and enantioselectivity. -(HAMADA*, Y.; KOSEKI, Y.; FUJII, T.; MAEDA, T.; HIBINO, T.; MAKINO, K.; Chem. Commun. (Cambridge) 2008, 46, 6206-6208; Grad. Sch. Pharm. Sci., Chiba Univ., Inage, Chiba 263, Japan; Eng.) -M. Paetzel

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