Background: COVID-19 pandemic constituted significant challenges in obstetric and pediatric health care services. Maternity and paediatrics staff are at high risk of occupational exposure to Covid-19, predominantly among pregnant women and children often asymptomatic for Covid-19 so that infections may go unrecognized. Staff development programs regarding infection prevention and control using nursing evidence-based practice regarding the covid -19 pandemic in the obstetrics -gynaecology and paediatrics wards were part of the needed response. Aim: Evaluate the effect of the staff development program on Nursing Evidence-Based performance regarding the Covid -19 pandemic in the obstetrics, gynaecology and paediatrics departements. Methodology: A quasi-experimental method and an interventional pre and post-test were used to study a sample of 112 nurses. A purposive sample technique was used to choose the sample from the obstetricsgynaecology and paediatrics departements using 4 tools to collect the data Results: The findings revealed a marked improvement in nurses' Knowledge of COVID-19 post-implementation of the program compared to pre-intervention. 79.5 % of the studied sample have good Knowledge regarding Covid-19 post implementation of the program, compared to 38.4 % pre-implementation. Also, 26.0% of them carried out the practice needed for Covid-19 most of the time post-program compared to 4.5% post program, and 28.0 % of the studied sample had a positive attitude regarding Covid-19 post implementation program, compared to 17.0 pre-implementation. Moreover, 91% of them were satisfied with the program compared to 9% dissatisfied. Conclusion: Translating evidence into practice during a Covid-19 pandemic to establishing a staff development program is the best possible provision of healthcare and guarantees preventive measures for the healthcare providers and is critical in facing Covid-19 and working in the complete chain of health care.Recommendations: A staff development program related to Covid-19 must be periodically held for maternity and pediatric health staff.