A significantly rising interest in the design of metal compounds as drugs and diagnostic agents is currently observed in the area of scientific inquiry, appropriately termed medicinal inorganic chemistry. Investigations in this area focus mostly on the speciation of metal species in biological media based on possible interactions of these metal ions with diverse biomolecules, in an effort to contribute to future development of new therapeutics or diagnostic agents. Metallopharmaceuticals used as anticancer agents, metal-mediated antibiotics, antibacterials, antivirals, antiparasitics, antiarthritics, antidiabetics and radio-sensitizing agents appear in therapeutic medicinal inorganic chemistry. The medicinal uses and applications of metals and metal complexes are of increasing clinical and commercial importance.

The objective of this present work was to develop and validate analytical method for quantitative determination of perindopril erbumine and amlodipine besylate in bulk as well as in tablet formulation. The chromatographic separation of the two drugs was achieved on a Varian Microsorb-MV 100-5 C18 column (150×4.6mm, 10 μm). The mobile phase constituted of acetonitrile: buffer (65:35) and pH adjusted to 2.6 with ortho- phosphoric Acid was delivered at the flow rate 1mL/min. Detection was performed at 210 nm. Separation was completed within 6 min calibration curves were linear with correlation coefficient between 0.99 to 1.0 over the concentration range of 2.5 to 15 µg/mL of perindopril erbumine and 10 to 60 µg/mL of amlodipine besylate The relative standard deviation (R.S.D.) was found <2.3%. The proposed method is precise, accurate, selective and rapid for the simultaneous determination of perindopril erbumine and amlodipine besylate.

Millions of people are affected by infectious diseases caused by micro-organisms. Further the widespread microbial resistance had renewed the interest in quest for new antitubercular, antimicrobial & antifungal agents. The present study deals with synthesis & evaluation of some substituted 2-aminothiazole derivatives for their antitubercular, antimicrobial and antifungal activity. 2-aminothiazole derivatives were synthesized by treating substituted acetophenones with thiourea in presence of bromine to give 2-amino 4-substituted phenylthizole and then further treated with chloracetyl chloride to give 2-chloro-N-(4-substituted phenylthizole-2-yl)-acetamide which on refluxing with primary amine gives 15 derivatives. All the synthesized compounds were characterized by IR, H-NMR and elemental analysis.All the synthesized compounds were screened for their antibacterial activity against S. aureus and E. coli by using cup plate agar diffusion method. The activity was measured in terms of zone of inhibition and compared with standard drug ciprofloxacin, sulfonamide. The aminothiazole derivatives were evaluated for antitubercular activity and their result were compared with standard streptomycin.

A series of 1, 3, 4-Oxadiazole derivatives have been synthesized and evaluated for antimicrobial and antidiabetic activities. The newly synthesized compounds have been characterized by IR, 1 H NMR and elemental analysis. All compounds have shown promising antimicrobial and antidiabetic activities when compared with standard drug ciprofloxacin and acarbose respectively. Compounds A2 ,B2 ,C1 ,D1 ,D2 ,E1 and E2 have shown promising antimicrobial activity while compounds A1 ,A2 ,B1 ,C1 ,D1 ,E1 and E2 have shown promising antidiabetic activity.

Thiadiazoles are synthesized by using aromatic acids and thiosemicarbazide. Schiff base reaction is followed and then thiadiazolotriazole derivatives are prepared by using hydrazine hydrate, isoniazid and unhydrous FeCl3. All the synthesized compounds were characterized by IR, 1H-NMR and CHN analyses. All the compounds were evaluated for antibacterial, antifungal & antitubercular activity. Compounds A1,B1, C1 and C4 have shown promising antibacterial activity, compounds A3, A4, B4, C2 and C4 have exhibited excellent antifungal activities, while compounds A2, A4, B2, B4, C2 and C4 showed anti-tubercular activity.