The article presents the results of empirical studies of correlation of culture and innovations. Sociocultural factors of innovative development have been revealed. The present research has established the dual nature of innovations that finds itself in a symbiosis of an innovation and a creativity product. This fact allows us to view this phenomenon as a result of interaction of the economic and sociocultural spheres of society's life activity: an innovative impulse arises from a person's desire to gain an economic benefit, on the one hand, and from a desire to reach the originality that is specified by traditions of a certain culture, on the other hand. Consequently, innovative activity depends directly on socio-cultural values that determine human dispositions, habits and motivations.Sh. Schwartz's calculation of value indices allowed us to reveal the human value priorities in twentyone countries of Europe in terms of their influence on person's innovative dispositions, using the data body of International comparison project "European Social Survey" (2012)(2013)(2014)(2015)(2016). It was shown that in the countries with dominant "Openness to Changes" values, inventiveness and innovativeness are more pronounced if compared to the countries where "Conservatism" values prevail. There has been demonstrated the special importance for innovative development of "Self-Transcendence" values that facilitate the formation of an environment favourable for implementing the institutional innovations. The research has proved that average Ukrainians have no value disposition to innovations. This fact creates a cultural barrier on the way of Ukraine's innovative development and requires governmental impact on these processes.The authors have taken into account the global modern development tendencies that manifest themselves in strengthening the countries' interdependency, particularly, in more rapid cultural convergence, gradual unification of values, with cultural diversity preserved. With this in mind, to intensify the innovative activity in Ukraine, the authors suggested a strategy of Ukraine's deeper integration into the world science and technology space as an equal partner as well as searching for its niche in a constantly developing world segment of creative and innovative activity, with cultural diversity being a powerful source of development.Keywords: innovations, innovative activity, cross-cultural analysis of innovations, person's innovative dispositions, socio-cultural innovation factors, Schwartz's value orientations for Ukraine, cultural barriers of innovative development

The analysis of formation of wave astrodynamics as the applied science that studying zonal-andwave structure of megasystems in the Universe is executed. The perspective of disclosure of physical essence of the phenomenon of rocks zonal disintegration around underground mine workings is analysed. The results of a research that received by means of well-known and new synergetic methods, which have discovered zonal-and-wave nature of the examined phenomenon, are described. The discovered phenomenon has been designated as zonal capsulation of mine working with definition of gradients of stresses, density, temperature and other factors of a power condition of the massif with formation of ring energy zones, their quantities, amount and shape, sinusoidal-and-wave stresses and ring areas of deformation. The regularities of distribution of matter and energy in systems with various large-scale levels have been investigated and accepted as comparative data for confirmation of level of convergence of the received results. Increase in large-scale level of system from micro to mega-and macrolevel led to equivalent increase in density of a core, constant of gravitation and the period of fluctuation of a surface, and the period of attenuation of wave fluctuations and a ratio of the sizes of energy zones remained constant. The received sedate dependence of a ratio of the sizes of energy zones for the examined systems coincides with the established verification of sedate dependences that describing a ratio of the sizes of energy zones in mine working's capsule which convergence reaches up to 100%. The received results are the incontestable proof of the uniform nature of interaction of the open evolving systems at all large-scale levels and allows to draw analogies during development of methodological approaches to the solution of similar problems.

Introduction Preterm delivery and its complications are among the biggest challenges and health risks in obstetrical practice. Several tocolytic agents are used in clinical practice, although the efficacy and side effect profiles of these drugs are not satisfying. The aim of this study was to investigate the uterus relaxant effect of the coadministration of β2‐mimetic terbutaline and magnesium sulfate (MgSO4) in an isolated organ bath and to perform in vivo smooth muscle electromyographic (SMEMG) studies in pregnant rats. In addition, we also investigated whether the tachycardia‐inducing effect of terbutaline can be reduced by the presence of magnesium, due to the opposite heart rate modifying effects of the two agents. Material and methods In the isolated organ bath studies, rhythmic contractions of 22‐day‐ pregnant Sprague–Dawley rats were stimulated with KCl, and cumulative dose–response curves were constructed in the presence of MgSO4 or terbutaline. The uterus‐relaxing effects of terbutaline were also investigated in the presence of MgSO4 in both normal buffer and Ca2+‐poor buffer. The in vivo SMEMG studies were carried out under anesthesia with the subcutaneous implantation of an electrode pair. The animals were treated with MgSO4 or terbutaline alone or in combination in a cumulative bolus injection. The implanted electrode pair also detected the heart rate. Results Both MgSO4 and terbutaline reduced uterine contractions in vitro and in vivo, furthermore, the administration of a small dose of MgSO4 significantly enhanced the relaxant effect of terbutaline, especially in the lower range. However, in Ca2+‐poor environment, MgSO4 was not able to increase the effect of terbutaline, indicating the role of MgSO4 as a Ca2+ channel blocker. In the cardiovascular studies, MgSO4 significantly decreased the tachycardia‐inducing effect of terbutaline in late pregnant rats. Conclusions The combined application of MgSO4 and terbutaline may have clinical significance in tocolysis, which must be confirmed in clinical trials. Furthermore, MgSO4 could substantially reduce the tachycardia‐inducing side effect of terbutaline.

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