Background: Non-steroidal anti-inflammatory drugs (NSAIDs) hypersensitivity is one of the leading cause of adverse reactions and a matter of concern in susceptible patients, with NSAIDs induced urticaria/angioedema (NIUA) being the commonest phenotype. Positive associations between the human leukocyte antigen (HLA) and NSAIDs hypersensitivity have been observed in different populations.
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