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A study was conducted to evaluate the effects of local drug delivery on subgingival plaque flora using hydroxypropylmethylcellulose (HPMC) and methylcellulose (MC) base material containing 40 % doxycycline (DOXY). Eleven patients who had at least four pockets exceeding 5 mm in depth associated with a single rooted tooth were selected from volunteers after an initial examination. Two of the pockets were chosen at random for insertion of the HPMC and MC strips twice a week for 6 w. One pocket received no treatment, and the other was debrided and root-planed only. Baseline and follow-up measurements at 0, 1, 3, 6, and 10 w included probing depth, gingival shrinkage, bleeding on probing and crevicular fluid flow. Subgingival bacterial samples were also taken for dark-field microscopy. In vitro drug release from the HPMC strips was greater than that from MC. Significant improvements in many clinical parameters occurred in the pockets treated with HPMC or MC strips, or mechanical debridement. There was a marked decrease in the relative proportions of motile organisms during and after treatment.

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ÖZETBu çalışmada parasetamolün hem doğrudan basım, hem de yaş granülasyon yöntemi ile değişik tablet formülasyonları hazırlanmış ve bunların optimizasyonu üzerinde çalışılmıştır.Bu amaçla, mikrokristalin sellüloz, sodyum nişasta glikolat ve hidrojene hint yağı gibi modern dağıtıcılar nişastanın yanında alternatif olarak kullanılmıştır. Ayrıca bağlayıcı derişkenliğininde yaş granülasyon yönteminde tabletin ve granülelerin fiziko-farmasötik ve fiziko-mekanik özellikleri üzerine etkisi karşılaştırmalı bir şekilde ve istatistiksel olarak incelenmiştir.Deney sonuçlarına göre, doğrudan basım ile hazırlanan formülün tüm özelliklerinin daha üstün çıkmasına rağmen, yaş yöntem ile hazır-lamak ekonomik yönden daha uygun bulunmuştur. SUMMARYIn this study, various tablet formulations of paracetamole were prepared using both direct compression and wet granulation method, and then these formulations were optimized. Redaksiyona verildiği tarih: 21 Mart 1984.