In light of the recent conflicts in Carthage over land use, cultural heritage preservation, and sustainable tourism, this works utilized a value-belief-norm (VBN) theoretical framework to consider psychological antecedents of residents' behavioral intentions to support cultural heritage tourism. As such, personal values, cultural worldview, awareness of consequences, ascription of responsibility, and subjective norms were considered antecedents of intentions to support cultural heritage tourism. Data were collected from 475 Carthage residents in nine neighborhoods adjacent to UNESCO World Heritage Sites using an on-site self-administered questionnaire. The proposed model was assessed through confirmatory factor analysis (to demonstrate sound psychometric properties across all 11 factors within the model), followed by structural equation modelling. Overall, 15 of the 19 proposed hypotheses were supported, ultimately contributing to 28% of the variance explained in residents' behavioral intentions to support cultural heritage tourism. Implications for theory and practice along with limitations and future research opportunities are discussed at the close of the paper.

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Given the expediency with which some U.S. governors have reopened their states to tourists, this research focuses on residents' responses to pro-tourism behaviour within the State of Georgia-one such state where contentious perspectives have been voiced. This work tests a social exchange model which includes four potential predictors of residents' pro-tourism behaviour. Eight of the 11 proposed model hypotheses were supported. Though perceived risk of COVID-19 was not a significant predictor, perceived positive and negative tourism impacts were the strongest. Local and state destination marketing organizations will be best served in applying our findings in efforts to continually monitor residents' perspectives as more individuals receive the COVID-19 vaccination.

Background Chloroquine (CQ) is a prototypical systemic and intradermal pruritogen for histamine‐independent (nonhistaminergic) itch in mice and humans. The predictive validity of this model is poorly documented in dogs. Hypothesis/Objective To determine pruritogenic and inflammatory effects of systemic and i.d. CQ injections in healthy dogs. Animals Ten healthy purpose‐bred laboratory beagles. Methods and materials All dogs were randomized to receive i.d. (200 and 400 µg/site), intravenous (2 mg/kg) and subcutaneous (3 mg/kg) CQ injections. Dogs were video‐recorded for 30 min after i.d. injections and for 300 min after i.v. and s.c. injections. Buffered saline injections served as controls for each route. Global wheal scores were evaluated at 30 min post‐i.d. injection by a blinded investigator. Results All dogs showed wheal and erythema at the CQ i.d. injection sites; global wheal scores of each CQ concentration were significantly increased compared to placebo (P ≤ 0.05). Blinded evaluation revealed no significant increase in generalized pruritic behaviour (pruritic seconds) after i.v. or s.c. administration of CQ. Intradermal injections induced mild localized acute pruritic behaviours at the site of injections at 200 µg (P = 0.06) and 400 µg (P = 0.27) CQ in dogs. Conclusion and clinical significance To the best of the authors’ knowledge, this is the first report which shows that i.d. CQ injections may induce acute inflammation in healthy dogs. By contrast to the systemic CQ‐induced pruritus reported previously in healthy mice and dogs, no significant pruritic behaviours were observed after CQ injection, regardless of the route of administration.

Background Scratching behaviours associated with intradermal (i.d.) injection of pruritogens such as histamine and compound 48/80 into the skin of mice and humans is the commonly used model to advance itch research and drug development. The predictive validity of this model is poorly documented in dogs. Objectives To evaluate the dose‐dependent effects of pruritogenic substances, each with a different mechanism of action, in healthy dogs. Animals Ten healthy laboratory beagles. Methods and materials All dogs were video‐recorded for 30 min post‐injection (mpi) of i.d. goat anti‐canine IgE (4 and 25 μg/site), histamine and compound 48/80 (50, 100, 200, 400 μg/site); two buffered saline injections served as controls. Two blinded investigators reviewed the pruritic behaviours of all video recordings. Global wheal scores were evaluated at 30 min by a blinded investigator. Results All dogs showed wheal and erythema at the pruritogen injection site; global wheal scores at 30 min of each substance significantly increased at all concentrations compared to control (P ≤ 0.05). A blinded evaluation revealed that all pruritogens induced mild acute pruritic behaviours at the site of injection. There was no injection site pain seen in any dog. Compared to controls, injections of pruritogens did not significantly affect the pruritic seconds or occurrence of pruritic episodes for any of the substances. Conclusions and clinical significance These preliminary results suggest that i.d. injections of the studied pruritogens can induce cutaneous wheal and flare response in healthy dogs; but inconsistencies occur in the induction of itch, even with the different concentrations of pruritogens.