In cone-beam breast CT, scattered photons form a large portion of the acquired signal, adversely impacting image quality throughout the frequency response of the imaging system. Prior simulation studies provided proof of concept for utilization of a hardware solution to prevent scatter acquisition. Here, we report the design, implementation, and characterization of an auxiliary apparatus of fluence modulation and scatter shielding that does indeed lead to projections with a reduced level of scatter. Methods: An apparatus was designed for permanent installation within an existing cone-beam CT system. The apparatus is composed of two primary assemblies: a "Fluence Modulator" (FM) and a "Scatter Shield" (SS). The design of the assemblies enables them to operate in synchrony during image acquisition, converting the sourced x-rays into a moving narrow beam. During a projection, this narrow beam sweeps the entire fan angle coverage of the imaging system. As the two assemblies are contingent on one another, their joint implementation is described in the singular as apparatus FM-SS. The FM and the SS assemblies are each comprised a metal housing, a sensory system, and a robotic system. A controller unit handles their relative movements. A series of comparative studies were conducted to evaluate the performance of a cone-beam CT system in two "modes" of operation: with and without FM-SS installed, and to compare the results of physical implementation with those previously simulated. The dynamic range requirements of the utilized detector in the cone-beam CT imaging system were first characterized, independent of the mode of operation. We then characterized and compared the spatial resolution of the imaging system with, and without, FM-SS. A physical breast phantom, representative of an average size breast, was developed and imaged. Actual differences in signal level obtained with, versus without, FM-SS were then compared to the expected level gains based on previously reported simulations. Following these initial assessments, the scatter acquisition in each projection in both modes of operation was investigated. Finally, as an initial study of the impact of FM-SS on radiation dose in an average size breast, a series of Monte Carlo simulations were coupled with physical measurements of air kerma, with and without FM-SS. Results: With implementation of FM-SS, the detector's required dynamic range was reduced by a factor of 5.5. Substantial reduction in the acquisition of the scattered rays, by a factor of 5.1 was achieved. With the implementation of FM-SS, deposited dose was reduced by 27% in the studied breast. Conclusions: The disclosed implementation of FM-SS, within a cone-beam breast CT system, results in reduction of scatter-components in acquired

Background In breast CT, scattered photons form a large portion of the acquired signal, adversely impacting image quality throughout the frequency response of the imaging system. Prior studies provided evidence for a new image acquisition design, dubbed Narrow Beam Breast CT (NB‐bCT), in preventing scatter acquisition. Purpose Here, we report the design, implementation, and initial characterization of the first NB‐bCT prototype. Methods The imaging system's apparatus is composed of two primary assemblies: a dynamic Fluence Modulator (collimator) and a photon‐counting line detector. The design of the assemblies enables them to operate in lockstep during image acquisition, converting sourced x‐rays into a moving narrow beam. During a projection, this narrow beam sweeps the entire fan angle coverage of the imaging system. The assemblies are each comprised of a metal housing, a sensory system, and a robotic system. A controller unit handles their relative movements. To study the impact of fluence modulation on the signal received in the detector, three physical breast phantoms, representative of small, average, and large size breasts, were developed and imaged, and acquired projections analyzed. The scatter acquisition in each projection as a function of breast phantom size was investigated. The imaging system's spatial resolution at the center and periphery of the field of view was measured. Results Minimal acquisition of scattered rays occurs during image acquisition with NB‐bCT; results in minimal scatter to primary ratios in small, average, and large breast phantoms imaged were 0.05, 0.07, and 0.9, respectively. System spatial resolution of 5.2 lp/mm at 10% max MTF and 2.9 lp/mm at 50% max MTF at the center of the field of view was achieved, with minimal loss with the shift toward the corner (5.0 lp/mm at 10% max MTF and 2.5 lp/mm at 50% max MTF). Conclusion The disclosed development, implementation, and characterization of a physical NB‐bCT prototype system demonstrates a new method of CT‐based image acquisition that yields high spatial resolution while minimizing scatter‐components in acquired projections. This methodology holds promise for high‐resolution CT‐imaging applications in which reduction of scatter contamination is desirable.