Chronic opioid usage (COU) for analgesia is common among patients with end-stage renal disease. In order to test whether a prior history of COU negatively affects post-kidney transplant outcomes, we retrospectively examined clinical outcomes in adult kidney transplant patients. Among 1064 adult kidney transplant patients, 452 (42.5%) reported the presence of various body pains and 108 (10.2%) reported a prior history of COU. While the overall death or kidney graft loss was not statistically different between patients with and without a history of COU, the cumulative mortality rate at 1, 3, and 5 years after transplantation, and during the entire study period, appeared significantly higher for patients with than without a history of COU (6.5, 18.5, and 20.4 vs. 3.2, 7.5, and 12.7%, respectively). Multivariate Cox regression analysis adjusted for potential confounding factors in entire cohorts and Cox regression analysis in 1:3 propensity-score matched cohorts suggest that a positive history of COU was significantly associated with nearly a 1.6- to 2-fold increase in the risk of death (hazard ratio 1.65, 95% confidence interval 1.04-2.60, and hazard ratio 1.92, 95% confidence interval 1.08-3.42, respectively). Thus, a history of chronic opioid usage prior to transplantation appears to be associated with increased mortality risk. Additional studies are warranted to confirm the observed association and to understand the mechanisms.

When using instruments written originally in a different language, the accuracy of translation is a crucial issue. The language and cultural interpretations can be barriers to healthcare access. Despite the need for a robust translation process, the existing literature offers little information about best practices for translation. Therefore, the purpose of this qualitative research was to illustrate a systematic approach to developing an accurate translation. We describe the process of developing an accurate and culturally relevant translation of the Connor-Davidson Resilience Scale (CD-RISC) from English to Arabic. The CD-RISC is a healthcare instrument to measure resilience and comprises 25 items rated on a 5-point scale, with higher scores reflecting increased resilience. Resilience is an important healthcare construct that can be applied to research on mental illness and adaptation ability. For instance, increased resilience appears to protect against diminished mental health. The translation process began as two individuals independently translated the CD-RISC into Arabic. A third person combined the two translations to produce a reconciled version. A fourth individual then back-translated the reconciled Arabic version to English. To resolve difficult-to-translate segments, the research team consulted with the instrument developer and then conducted cognitive testing with six individuals. A cultural research methodologist participated throughout the process. Among the 28 text segments in the CD-RISC (the title, instructions, scoring, and 25 items), the best equivalency in Arabic came from eight segments of each forward-translation. The remaining 12 segments were similar. Each the back-translation and cognitive testing contributed to seven revisions. The robust translation procedures detailed can be used by researchers to develop best-quality translations.

Aim: Describe naturalistic clinical course over 14 weeks in a mixed adolescent and a young-adult patient group diagnosed with developmental delays and catatonia, when the frequency of maintenance electroconvulsive therapy (M-ECT) was reduced secondary to 2020 COVID-19 pandemic restrictions.Methods: Participants were diagnosed with catatonia, and were receiving care in a specialized clinic. They (n = 9), F = 5, and M = 4, ranged in age from 16 to 21 years; ECT frequency was reduced at end of March 2020 due to institutional restrictions. Two parents/caregivers elected to discontinue ECT due to concern for COVID-19 transmission. Majority (n = 8) were developmentally delayed with some degree of intellectual disability (ID). Observable symptoms were rated on a three point scale during virtual visits.Results: All cases experienced clinically significant decline. Worsening of motor symptoms (agitation, aggression, slowness, repetitive self-injury, stereotypies, speech deficits) emerged within the first 3 weeks, persisted over the 14 week observation period and were more frequent than neurovegetative symptoms (appetite, incontinence, sleep). Four participants deteriorated requiring rehospitalization, and 2 among these 4 needed a gastrostomy feeding tube.Conclusion: Moderate and severe symptoms became apparent in all 9 cases during the observation period; medication adjustments were ineffective; resuming M-ECT at each participant's baseline schedule, usually by week 7, resulted in progressive improvement in some cases but the improvement was insufficient to prevent re-hospitalization in 4 cases. In summary, rapid deterioration was noted when M-ECT was acutely reduced in the setting of COVID-19 related restrictions.

No abstract