The key to achieving favourable results in this particular type of developmental anomaly is accurate diagnosis and treatment planning. The health of the periapical osseous tissues appears to be the provital factor for tooth retention. A favourable outcome can only be achieved with a comprehensive treatment approach that effectively manages all local factors that are contributing to the disease process.

Introduction: Millions of teeth are saved each year by root canal therapy. Although current treatment modalities offer high levels of success for many conditions, an ideal form of therapy might consist of regenerative approaches in which diseased or necrotic pulp tissues are removed and replaced with healthy pulp tissue to revitalize teeth. The practice of dentistry is likely to be revolutionized by biological therapies based on growth and differentiation factors that accelerate and/or induce a natural biological regeneration. Literature review: This review summarizes current knowledge, barriers, and challenges in the clinical use of adult stem cells, scaffolds, and growth factors for the development and evaluation of regenerative endodontic therapies.

Introduction and objective: The aim of the present study was to compare root canal preparation with rotary ProTaper files and hand ProTaper files to find a better instrumentation technique for maintaining root canal geometry with the aid of computed tomography. Material and methods: Twenty curved root canals with at least 10 degree of curvature were divided into 2 groups of 10 teeth each. In group I the canals were prepared with hand ProTaper files and in group II the canals were prepared with rotary ProTaper files. Image analysis was performed at four levels 4mm, 6mm, 9mm, and 12mm from the root apex to assess changes in canal transportation and centering ratio using computed tomography (CT). Results: Data suggest that rotary ProTaper files presented the best outcomes for both variables evaluated. Rotary ProTaper files caused lesser transportation and remained better centered in the canal than hand ProTaper files. Conclusion: The canal preparation in natural teeth with rotary Protaper files showed lesser transportation and better centering ration than hand ProTaper files.

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