Protein Tyrosin Kinase 7 (PTK7) is upregulated in several human cancers; however, its clinical implication in breast cancer (BC) and lymph node (LN) is still unclear. In order to investigate the function of PTK7 in mediating BC cell motility and invasivity, PTK7 expression in BC cell lines was determined. PTK7 signaling in highly invasive breast cancer cells was inhibited by a dominant-negative PTK7 mutant, an antibody against the extracellular domain of PTK7, and siRNA knockdown of PTK7. This resulted in decreased motility and invasivity of BC cells. We further examined PTK7 expression in BC and LN tissue of 128 BC patients by RT-PCR and its correlation with BC related genes like HER2, HER3, PAI1, MMP1, K19, and CD44. Expression profiling in BC cell lines and primary tumors showed association of PTK7 with ER/PR/HER2-negative (TNBC-triple negative BC) cancer. Oncomine data analysis confirmed this observation and classified PTK7 in a cluster with genes associated with agressive behavior of primary BC. Furthermore PTK7 expression was significantly different with respect to tumor size (ANOVA, p = 0.033) in BC and nodal involvement (ANOVA, p = 0.007) in LN. PTK7 expression in metastatic LN was related to shorter DFS (Cox Regression, p = 0.041). Our observations confirmed the transforming potential of PTK7, as well as its involvement in motility and invasivity of BC cells. PTK7 is highly expressed in TNBC cell lines. It represents a novel prognostic marker for BC patients and has potential therapeutic significance.

The article provides an overview of scientific research on the relationship of musicality and general intelligence. It is noted that the problem of the relationship between musicality, musical achievements and intelligence is interdisciplinary. It is significant for general and music psychology as well as for the theory and practice of music education. There is a shortage of empirical and theoretical works on this topic in the modern Russian-language scientific literature, and that is what determines the relevance of the overview presented. The article discusses the role of general intelligence in the formation of a musical professional and musical and educational achievements. There is a continuity in the development of scientific ideas and approaches from the beginning of the last century to modern research. Musical abilities are shown to be largely determined by the intellectual potential of the individual, which explains the association of musical abilities with academic performance and abilities in non-musical areas. Modern approaches view musicality as a polymorphic entity which is better described in terms of multidimensional musical behavior. The formation of a professional in the musical field makes the relationship between musicality and intelligence more complex; it begins to be mediated by a combination of factors, a significant place among which is shared intelligence.

We studied the effect of the factors affecting the recognition of the emotional content of the music. We tested hypotheses about the influence of the valence of the music, ethnic style and the listening experience on the success of music recognition. The empirical study involved 26 Russian musicians (average age of 25,7 years). For the study of musical perception we used bipolar semantic differential. We revealed that the valence of music material affects the recognition of the emotional content of music, and the ethno style does not. It was found that senior students recognize the emotional context of the music more effectively. The results show the universal nature of emotional and musical ear, equally successfully recognizing music of different ethnic style, as well as support the notion of higher significance of negative valence of emotional content in the process of musical perception. A study of factors influencing the emotional understanding of music is important for the development of models of emotion recognition, theoretical constructs of emotional intelligence, and for the theory and practice of music education.

The article provides an overview of modern foreign psychological research devoted to the study of musicality. It describes in details Gold-MSI method (Goldsmiths Musical Sophistication Index), developed by psychologists at the University of Goldsmith to diagnose the level of musical development. In Russia, this technique is unknown, although it is widely used in foreign studies, it is standardized and has displayed good psychometric properties. The article presents the results of the initial testing of the Russian version of the Gold-MSI technique on a sample of 107 participants. It is shown that the Russian version of the methodology has a satisfactory reliability and validity and can be used for research purposes