Scientific data concerning the impact of emotional stress to human genomic instability very seldom describes in literature. For many scientists this connection is not supposed to be obvious, although oncologists and psychologists know that a prolonged state of heightened emotional tension is fraught with serious problems for the nervous-immune-endocrine system of the organism. Moreover, oncologists know that cancer is often the result of resentment and loneliness. At the same time, the role of genome instability in processes of tumor induction and progression is proved very correctly. In the report will be paying attention to 3 aspects of human life in context of emotional stress expression and its connection with genomic instability: environmental pollution, genomic predisposes, ethic and social-economic problems. The report will contain data from literature and results of own research directed to the analyzing the impact of the degree of emotional stress expression on the children's and adults' genomic instability. Special attention will be paid to the investigation how emotional state of parents and teachers impact on young children's genomic instability. Methods. For evaluation of stress expression levels we used the complex of standard psychological tests: questionnairesfor adults and 8-coloured M. Luscher's test-for children. Estimation of genomic instability was carried out in blood cultures by test on chromosome aberration and micronuclei test with Cytochalasin B. Alteration of biochemical indices were detected by standard methods.

No abstract

This article presents new results of the investigation of anxiety and balance of the departments of autonomic nervous system of 178 healthy 5 -7 years old children living in 2 different districts of Magnitogorsk town. It is shown that the state of increased and high anxiety more often was detected among children living around the Magnitogorsk Iron and Steel Combine (MISC). Among these children, an imbalanced work of the departments of autonomic nervous system (mostly ergotropic tone) found out more often than among children, living in the other district of the town. The increased genome instability as well as individual sensitivity of children's genome to standard genotoxic load determined in vitro in peripheral blood cultures (micronucleus test with Cytochalasin B) correlated with children's psychosomatic characteristics, especially for those who lived around the MISC.