Abstract:We have developed a one-pot ring-closing metathesis (RCM)/oxidation methodology to yield various 2-quinolines from 2-vinyl-N-allylaniline derivatives. This is a first example of an oxidation involving methylene (CH 2 ) groups with modified Grubbs-type ruthenium complexes. Hence, this adds an example of a non-methathesis reaction using a ruthenium carbene catalyst.

One-Pot Ring-Closing Metathesis (RCM)/Oxidation by an Assisted Tandem Ruthenium Catalysis for the Synthesis of 2-Quinolones. -It provides a new approach to 2-quinolones. Some limitations are observed. -(KATO, H.; ISHIGAME, T.; OSHIMA, N.; HOSHIYA, N.; SHIMAWAKI, K.; ARISAWA*, M.; SHUTO, S.; Adv. Synth. Catal. 353 (2011) 14-15, 2676-2680, http://dx.doi.org/10.1002/adsc.201100303 ; Fac. Pharm. Sci., Hokkaido Univ., Sapporo 060, Japan; Eng.) -Jannicke 13-172