Platelet-rich plasma can enhance the proliferation of human adipose-derived stem cells and human dermal fibroblasts. These results support clinical platelet-rich plasma application for cell-based, soft-tissue engineering and wound healing.
Autologous platelet-rich plasma contains multiple growth factors. We performed a side-by-side (half-side) test between the platelet-rich plasma (PRP)-treated and control (untreated) sides of a split-thickness skin graft donor site, and compared the number of days until epithelialization and pain during gauze change. On day 13 after surgery, we performed punch biopsy on the two sides and for adjacent normal skin tissue and compared the epidermal thickness and numbers of collagen fibers and newly formed vessels in the dermis by H&E staining, elastica van Gieson staining, and α-smooth muscle actin (α-SMA) immunostaining. Epithelialization progressed more rapidly, pain during gauze change was milder, and the epidermal thickness and number of newly formed vessels in the dermis were significantly greater on the PRP-treated side. This study revealed that PRP promotes epithelialization and angiogenesis of split-thickness skin graft donor sites.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.