The stereospecificity of the D-2 receptor mediating the growth hormone (GH) response to apomorphine (Apo) and the D-2 receptor regulating prolactin (PRL) secretion were investigated in 10 normal men by examining the effects of cis-flupenthixol (cis-Fx) and trans-flupenthixol (trans-Fx). cis-Fx (1 mg six hourly times four doses) antagonized the GH response to Apo HCl (0.5 mg sc) and increased basal serum PRL concentrations whereas the trans-isomer showed no effect. These findings (a) provide further evidence that the GH response to Apo is mediated by stimulating dopamine (DA) receptors, and, (b) demonstrate stereospecificity of the DA receptor mediating the GH response to Apo and the DA receptor regulating PRL secretion.
Organisasi ketika menerapkan sistem atau aplikasi untuk berbagai keperluan tentu berharap agar dapat digunakan secara optimum. Untuk memastikan kondisi ini, pengukuran tingkat ketersiapan pengguna menjadi penting. Kajian ini menjelaskan HOT FIT sebagai salah satu model untuk memahami aspek-aspek penting dalam penerapan aplikasi dan pemanfaatannya dalam pengukuran tingkat kesiapan. Ada beberapa kelebiha metode ini selain sederhana juga komprehensif. Kajian-kajian lain mendukung efektivitas metode ini. Indkator yang digunanaka dengan menggunakan metode HOT FIT dalam kajian ini dapat digunakan sebagai landasan proses pengukuran.
ICT services are an essential element in modern organizations. Understanding the workings of service systems with specific frameworks helps manage services well. One of the services in this management is the Service Desk or Helpdesk. This study aims to explain the Service Desk using the ITIL V.3 framework. The method used is descriptive qualitative using relevant references. The results of this study indicate that ITIL V.3 can be used to describe the management of the Service Desk accurately.
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