A patient presented with frequent episodes of spontaneous hypoglycaemia due to a solitary fibrous tumour of pleural origin, secreting incompletely processed pro-insulin-like growth factor II (big IGF-II). Somatostatin receptors were demonstrated in the tumour by 111 inlabelled octreotide scintigraphy, but despite maximal doses of octreotide, there was no suppression of big IGF-II secretion and the hypoglycaemia persisted. The combination of GH and glucocorticoid therapy abolished the hypoglycaemia.

No abstract

Antibodies to secretin have been reported using crude secretin conjugated to albumin (Young, Lazarus, Chisholm and At• kinson 1967). The present study reports the production of antibodies against microgram quantities of synthetic secretin and natural secretin in the unconjugated form.