Introduction Coronavirus Disease (COVID-19) caused by Novel Coronavirus named as Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) was declared Pandemic by The World Health Organization (WHO) and a Public Health Emergency of International Concern (PHEIC) on January 30, 2020. Many COVID-19 vaccines have been developed, including CoronaVac vaccines by Sinovac. Health care workers, along with medical clerkship students are the priority to receive the vaccine. However, the Adverse Events Following Immunization (AEFI) of the CoronaVac remains unclear. This study aims to describe and analyze the adverse events following immunization (AEFI) of COVID-19 vaccination in medical students in clerkship programs. Method We conducted a cross-sectional study using a questionnaire to assess AEFI after CoronaVac vaccination among medical clerkship students. A Chi-Square test with 95 % of CI was used to determine whether gender correlated with symptoms of AEFI. Result We identified 144 medical clerkship students. The most common AEFI of SARS-CoV-2 vaccinations was localized pain in the injection site during the first dose with 25 (45 %) reports and the booster dose with 34 (67 %) reports. Then followed by malaise, the first dose with 20 (36 %) reports and the booster dose with 21 (41 %) reports. Other symptoms like headache, fever, shivering, sleepiness, nausea, dysphagia, and cold were also reported. Conclusions CoronaVac SARS-COV-2 vaccine has several mild symptoms of AEFI and not correlated with gender. Nevertheless, follow-up after vaccination is needed to prevent immunologic responses that may occur in some patients.

Diazinon is an organophosphate type pesticide that is still often used by farmers in Indonesia, with the effect of inhibiting the acetylcholinesterase enzyme, giving rise to the accumulation of acetylcholine in the synapse gap which will lead to incoordination, convulsions and death in insect pests. Apart from having the neurotoxic effects of diazinone it can also damage cells through the mechanism of oxidative stress. Diazinone poisoning has a high potential to cause damage to the kidney organs, because the diazinone excretion pathway and its active metabolites are through the urinary system. The purpose of this study was to determine the effect of diazinone on the liver and renal wistar male kidney. Diazinone dosage of 40 mg / kgBW, given to mice twice a day for 5 days, with each given as much as 5 ml using the gastric sonde. The research sample was in the form of rat blood taken intracardiac to examine BUN levels, serum creatinine, SGOT, SGPT, and GSH, then kidney and liver rats were taken to make histopathological preparations and MDA examinations. Analysis of this research data using the T-test for all variables. There were significant differences between groups of rats given diazinone and groups of rats not given diazinone based on levels of BUN, creatinine, SGOT, SGPT, GSH and MDA. In the group of mice not given diazinone, kidney histopathology was better than those given diazinon. Keywords: diazinon, pesticides, organophosphates

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