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ObjectiveThe aim of this study is to evaluate the influence of metal ions present in soil as well as in the leaves samples of Calendula officinalis and Phlebodium decumanum for the treatment of psoriasis. MethodsLooking at the objective, soils and leaves samples were estimated for metal ions by atomic absorption spectrophotometer to determine the influence in anti-psoriatic activity. Thereafter Imiquimod-induced dermatitis lesions were created in grouped mouse. Two plant extracts (aqueous) separately as well as in combinations and standard Retino-A (0.05%) were used.Psoriasis severity index (PSI) was evaluated by phenotypic (redness, erythema, and scales) and histological features (epidermal thickness). Further content of phytochemicals in terms of extract was correlated with the effect of psoriasis activity. Results:We observed redness, erythema and scales and the histological features and found a progressive reduction (P < 0.05) in the severity of psoriatic lesions (redness, erythema, and scales) from day 7 to 21 st day and decreased epidermal thickness in animals treated with combined extracts at the dose of 200 mg/kg b.w. Furthermore plant samples procured from Nandi Hill's, Bangalore, showed better uptake of metals with respect to Fe (2.05 mg/kg), Cu (0.78 mg/kg) and Zn (1.12 mg/kg) which showed positive impact on procurement of maximum amount of extracts that further correlated with the activity, indicated significant reduction of psoriatic lesions. ConclusionResults revealed that significant dose dependent antipsoriasis activity of combined aqueous extracts of Calendula officinalis and Phlebodium decumanum as well as metal ions are also had impact on the procurement of extracts and said activity.