Background: COVID-19 pandemic is not over yet, and the clinical manifestations of this newly emerged disease vary due to the rapid mutation of SARS-CoV-2 as its causative agent. The SARS-CoV-2 infection will stimulate the release of proinflammatory cytokines in large amounts, which further leads to hypercoagulation. The aim of this study is to describe a case of COVID-19 with hypercoagulation and what can be done to prevent serious complications. Case: 1.5-month-old baby boy presented with a complaint of coughing for 10 days. It was accompanied by persistent fever, diarrhea, and vomiting, but no shortness of breath or rhinorrhea was reported. It was known that his parents, whom he was living with, were self–isolating due to COVID – 19. On physical examinations, his vital signs were within normal limits except for axillary temperature, which was tested at 38.3°C. Laboratory results showed a prolongation of coagulation time (PT: 8,3 seconds, APTT: 23,2 seconds), elevated D-Dimer (>10.000 ng/mL), and a positive COVID-19 PCR test. He was diagnosed with a hypercoagulation state in severe COVID-19 and received both supportive and anticoagulant therapy. His condition improved, and he was discharged in good condition after 12 days of hospitalization. Conclusion: In order to get good outcomes, thorough examinations and comprehensive management have to be ensured in patients with a hypercoagulation state due to severe COVID-19.

Background: In 2018, the Indonesian Pediatric Society stated that there were 1,220 children suffering from Type 1 Diabetes Mellitus. This might be an iceberg phenomenon due to a large number of children and adolescents in Indonesia. Diabetic ketoacidosis is one of the Type 1  Diabetes Mellitus acute complications that could be fatal. The problem is that our society isn't familiar with this condition, and it leads to delayed diagnosis and treatment. Case: A 16 – year – old girl was hospitalized due to right lower abdominal pain, nausea, vomiting, decreased appetite, and fever for 3 days. The next morning, she became unconscious with a Glasgow Coma Scale of E1V1M6. Her blood tests showed blood glucose levels of 551 mg/dL, C – Peptide of 0,65 ng/mL, pH of 6,81, and cHCO3 of 3 mmol/L. Her urine tests showed ketonuria of +4. She was diagnosed with Severe Diabetic Ketoacidosis and Cerebral Edema. She received 8 litre/minute of O2 NRM, 10 ml/kg of 0,9% NaCl in 1 hour continued with 1,5 times maintenance need + 5 mmol/kg/day of KCl, 0,1 IU/kg/hour of insulin, and 1 g/kg of mannitol. Renal function monitoring showed daily increases in serum creatinine to 9,2 mg/dL on the day – 7. This pre-renal acute kidney injury was thought to be due to dehydration. She was then referred to a higher-level hospital for hemodialysis. Conclusions: Diabetic Ketoacidosis in children shows a wide range of clinical manifestations. Therefore, awareness of this condition is of utmost importance in reducing patients' morbidity and mortality.