Radioimmunoassays for five oestrogen metabolites in urine are described; they are oestrone 3-glucuronide, oestradiol 3-glucuronide, oestradiol 17 beta-glucuronide, oestriol 3-glucuronide and oestriol 16 alpha-glucuronide. These assays have proved accurate and reliable and can be performed rapidly; they have been carried out directly in diluted menstrual cycle urine and pregnancy urine. No sample pretreatment was required. Preliminary results suggest that clinically useful information can be obtained by performing these assays on random urine specimens.
Polyaminhaltige Bolaamphiphile binden an DNA in einer Weise, dass diese eine kompakte, wohldefinierte Faltung einnimmt. Die Aggregate widerstehen dem Abbau durch Nucleasen, und sie können zur effizienten Transfektion von Eierstockzellen aus Hamstern dienen. Durch den Einbau eines geringen Prozentsatzes eines Polyethylen‐Bolaamphiphils wird die unspezifische Aufnahme verringert; die zielgerichtete Transfektion menschlicher T‐Zelllinien wurde demonstriert anhand eines Anti‐CD3‐Antikörper/Bolaamphiphil‐Konjugats, das zu 0.004 % in die supramolekulare Anordnung eingebaut wurde.
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