Background A first-dose of various vaccines provides acceptable protection against infections by SARS-CoV-2 and evolution to the most severe forms of COVID-19. The recombinant adenovirus (rAd)-based vaccine, Gam-COVID-Vac (Sputnik V), was proven efficacious but information about effectiveness in the real-world setting is lacking. The aim of our study was to investigate the association between the rollout of the first component (rAd26) of Gam-COVID-Vac and PCR-positive tests, hospitalisations and deaths. Methods We conducted a retrospective cohort study which analyzed individuals aged 60-79 who self-registered in the online vaccination system of the Province of Buenos Aires, Argentina, from December 29, 2020 to March 21, 2021. Exclusion criteria were having a previous positive RT-PCR or antigen tests for SARS-CoV-2, having received other vaccines, or two doses of any vaccine. Proportions of new laboratory-confirmed SARS-CoV-2 infections, hospitalisations and deaths until 83 days of vaccination were compared between vaccinated and unvaccinated subjects. Vaccine effectiveness for the three outcomes was calculated as (1–OR) × 100. Kaplan-Meier cumulative incidence curves were constructed. Findings During the study period 415995 registered subjects received the first component of Gam-COVID-Vac; 40387 belonged to the 60-79 age group, and were compared to 38978 unvaccinated. Vaccine effectiveness for preventing laboratory-confirmed infections was 78•6% [CI 95% 74·8 - 81·7]; and for reducing hospitalizations and deaths was, respectively, 87·6% [CI 95% 80·3 - 92·2] and 84·8% [CI 95% 75·0 - 90·7]. Effectiveness was high across all subgroups. Interpretation Similarly to other vaccines, the administration of one dose of Gam-COVID-Vac was effective for a wide range of COVID-19–related outcomes. Funding This study did not receive any funding.

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Introduction:The controversy over the presence of empathic decline within the course in students of medicine, dentistry and health sciences in general, has not fully been studied. This controversy could be partially solved if massive studies of empathy levels are made in similar cultural, social and economic contexts. Material and Methods:Empathy levels within the course were studied in eighteen dental schools from six countries in Latin America (2013). The mean of the empathy levels were used to study the behavior between first and fifth academic years. The values of empathy levels within the course were observed by applying the Jefferson Scale of Physician Empathy, the Spanish version. All these studies were cross-sectional. The value of means observed, were subjected to regression studies and further adjustment curves were obtained and the coefficient of determination were calculated. Results: Six different models of behavior were observed, which found that five of them suffer empathic decline within the course, but with different final results: in some the decline persists until the fifth academic year and in others, this decline 'recovers' persistently until the fifth academic year. The sixth model is characterized by a constant and persistent increase of levels of empathy within the course until the last academic year. Discussion: There are six different models for the behavior of means of levels of empathy within the course evaluated by a common methodology in eighteen dental schools from six countries of Latin America. These findings support the existence of variability of empathic response and a comprehensive approach is needed to find the causes that give rise to this variability. Conclusion:In dental students of Latin America, there is variability in the behavior of the distribution in means between the academic years of the dentistry schools examined in this study.

In Argentina, RSV and influenza activity overlapped during the winter months. RSV season tended to begin prior to the influenza season, and showed more variation in start week by region. Influenza seasons tended to vary more in duration than RSV seasons.

Objetivo: Evaluar la prevalencia de anticuerpos para SARS Cov-2 en el Barrio Villa Azul, del partido de Quilmes, junto con otras variables demográficas y de movilidad. Métodos: Estudio descriptivo de corte transversal realizado a través de una muestra probabilística sistemática. El tamaño de la muestra fue de 311 casos y consintieron la aplicación del test 284 casos. Fue aplicada una encuesta al 100% de los casos testeados. La información fue procesada con software SPSS 23 y los análisis consideraron la ponderación de la muestra de acuerdo al diseño equiprobabilístico establecido. Resultados: El 61% eran mujeres. La media de edad era de 40 años, la estructura poblacional era similar a la del universo. La presencia de anticuerpos fue del 14,8% de los casos, la mayoría en mujeres y de 40 años que no salieron a trabajar y no utilizaron transporte público. El ser trabajador de la salud no representó un riesgo acrecentado para el contagio. Se observa que de cada un caso sintomático existirían 1,2 asintomáticos. Conclusiones: Hubo una prevalencia mayor de personas con anticuerpos que en otros estudios, aunque comparando territorios similares la prevalencia de anticuerpos fue menor y esto pude ser una consecuencia de un abordaje territorial oportuno. La seroprevalencia fue predominantemente en mujeres y esto no indicaría mayor contagio en este sexo ya que existe incertidumbre en la relación entre infección y anticuerpos. Se observó que los contagios podrían haber sido dentro del hogar o el entorno comunitario ya que afectó a personas que no salían a trabajar.