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We studied the effects of the H 2 S donor Na 2 S on the mean arterial blood pressure (MAP) and heart and breathing rates of anesthetized Wistar rats in the presence and absence of captopril. Bolus administration of Na 2 S (1-4 µmol/kg) into the right jugular vein transiently decreased heart and increased breathing rates; at 8-30 µmol/kg, Na 2 S had a biphasic effect, transiently decreasing and increasing MAP, while transiently decreasing heart rate and increasing and decreasing breathing rate. These results may indicate independent mechanisms by which H 2 S influences MAP and heart and breathing rates. The effect of Na 2 S in decreasing MAP was less pronounced in the presence of captopril (2 µmol/l), which may indicate that the renin-angiotensin system is partially involved in the Na 2 S effect. Captoprildecreased H 2 S-induced NO release from S-nitrosoglutathione, which may be related to some biological activities of H 2 S. These results contribute to the understanding of the effects of H 2 S on the cardiovascular system.

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