Weexamined the relationship between left ventricular hypertrophy (LVH) and renal and retinal damage in 174 untreated patients with essential hypertension. As an index of renal and retinal damage, we examined proteinuria and retinal vascular change. LVH was diagnosed according to left ventricular mass obtained from echocardiography. Of the hypertensive patients, 111 patients (64% ) had LVH. The incidences ofproteinuria and advanced retinal vascular change werehigher in patients with LVH than in those without LVH. In a multiple regression model, there wasa significant positive correlation between left ventricular mass and proteinuria, as well as diastolic blood pressure, sex, age and body mass index. In conclusion, proteinuria is related to elevated left ventricular mass in patients with essential hypertension.

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We examined the gender-related differences in target organ damage in 220 untreated patients with essential hypertension (106 men and 114 women

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Objective and Methods We examined the prognostic significance of electrocardiographic predictors (number of leads with ST depression, maximal ST depression, QT dispersion), C-reactive protein, fibrinogen, myosin light chain 1 and creatine kinase MB fraction in 62 patients with unstable angina showing ST depression during an anginal attack. Results During the 90-day follow-up period, 15 patients (24 %) exhibited new cardiac events (death, myocardial in-farction or urgent revascularization). Using multivariate analysis, the number of leads with ST depression [relative risk 6.305 (95 % confidence intervals 1.831-21.71), p<0.01] during an anginal attack was found to be an independent risk factor to predict cardiac events. Other predictors did n ot have prognostic significance. Conclusion The number of leads with ST depression during an anginal attack is an independent risk predictor for newcardiac events in high risk patients with unstable angina. (Internal Medicine 41 : 270-276, 2002)