Aim: To assess the malocclusion and esthetic perception among young adults in Riyadh region. Methodology: A total of 667 subjects aged above 6 years were included in this study. Link containing questionnaires were sent through social media, email, and WhatsApp. Questions were related to the effect of malocclusion on oral health such as dental caries, gum disease, difficulty in tooth brushing, perception of their teeth in the way of alignment, and smile personality. Results: 54.1% of participants said malocclusion can cause dental caries, 63.3% said it will lead to gum disease, and 72% were of the opinion that it will make tooth brushing difficult. 27.9% of study subjects were not happy with the alignment of their teeth. None of the responses were found to be statistically significant according to age ( P > 0.05). Most of the questions were statistically significant according to gender ( P < 0.05). Conclusion: Majority of study subjects had good knowledge about malocclusion and oral health. Perception about esthetics was more among women than men. More than 90% of subjects thinks beautiful smile is a part of personality.