Resumo: Este estudo teve por objetivo avaliar a percepção de estresse entre estudantes de enfermagem do último semestre de uma Instituição de Ensino Superior (IES) particular, no sudoeste da Bahia. Trata-se de uma pesquisa descritiva, de natureza qualitativa. A coleta de dados foi realizado através de entrevistas com roteiro semiestruturado, no período de 05 a 10 de maio de 2017. Participaram 15 estudantes de enfermagem matriculados no turno vespertino. As entrevistas, após realizadas, foram transcritas para o programa Word/Starter 2010. Os dados foram analisados visando a identificação das categorias e unidades temáticas a partir da utilização do referencial de Bardin. A análise foi ancorada no referencial teórico escolhido. Após apreciação dos dados, emergiram quatro categorias a saber: conceito do estresse; compreensão dos sinais e sintomas do estresse; fatores estressantes percebidos diariamente e fatores estressantes esperados na vida acadêmica e futuro profissional. Os resultados do estudo levam à reflexão de que é preciso que no meio acadêmico haja medidas preventivas ou redutoras de estresses, para que a aprendizagem se efetive de forma satisfatória e os alunos sejam preparados para o enfrentamento dos desafios da profissão.Descritores: Enfermagem; Estudantes de enfermagem; Percepção do estresse. Perception of Stress among Nursing Students of a Teaching InstitutionAbstract: This study aimed to evaluate the stress among nursing students in the last semestre of a private teaching istitution in the southwestern region of Bahia. It is a descriptive and qualitative research. The data collection was performed by interviews with semi-structured script, in the period between 05 to 10 of May 2017. 15 nursing students enrolled in the afternoon period participated of the study. The interviews were transcribed into the Word / Starter 2010 program. The data were analyzed aiming the identification of the categories and thematic units from the use of Bardin reference. The analysis was made according to the chosen theoretical reference. After evaluating the data, four categories were highlighted: the concept of stress; Understanding of the signs and symptoms of stress; Stress factors perceived daily and stress factors expected in academic life and professional future. The results of the study lead to the reflection that there must be preventive or stress-reducing measures in the academic world, so that the learning process is satisfactory and students are prepared to face the challenges of the profession Keywords: Nursing; Nursing students; Perception of stress. IntroduçãoUm dos assuntos recorrentes na atualidade, o qual pode interferir diretamente na qualidade de vida do indivíduo, é o estresse. O termo "estresse" tem sua origem na física e nesta tem como definição o nível de deformidade suportada por uma estrutura quando é submetida a um esforço (LIPP, 2009). Tempos depois, o termo passou a ser utilizado pela medicina e 1 Graduanda em Enfermagem pela Faculdade Independente do Nordeste -FAINOR. taimoreiraa@gmail.com>

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Docetaxel (DTX) is a non-selective antineoplastic agent with low solubility and a series of side effects. The technology of pH-sensitive and anti-epidermal growth factor receptor (anti-EGFR) immunoliposomes aims to increase the selective delivery of the drug in the acidic tumor environment to cells with EFGR overexpression. Thus, the study aimed to develop pH-sensitive liposomes based on DOPE (dioleoylphosphatidylethanolamine) and CHEMS (cholesteryl hemisuccinate), using a Box–Behnken factorial design. Furthermore, we aimed to conjugate the monoclonal antibody cetuximab onto liposomal surface, as well as to thoroughly characterize the nanosystems and evaluate them on prostate cancer cells. The liposomes prepared by hydration of the lipid film and optimized by the Box–Behnken factorial design showed a particle size of 107.2 ± 2.9 nm, a PDI of 0.213 ± 0.005, zeta potential of −21.9 ± 1.8 mV and an encapsulation efficiency of 88.65 ± 20.3%. Together, FTIR, DSC and DRX characterization demonstrated that the drug was properly encapsulated, with reduced drug crystallinity. Drug release was higher in acidic pH. The liposome conjugation with the anti-EGFR antibody cetuximab preserved the physicochemical characteristics and was successful. The liposome containing DTX reached an IC50 at a concentration of 65.74 nM in the PC3 cell line and 28.28 nM in the DU145 cell line. Immunoliposome, in turn, for PC3 cells reached an IC50 of 152.1 nM, and for the DU145 cell line, 12.60 nM, a considerable enhancement of cytotoxicity for the EGFR-positive cell line. Finally, the immunoliposome internalization was faster and greater than that of liposome in the DU145 cell line, with a higher EGFR overexpression. Thus, based on these results, it was possible to obtain a formulation with adequate characteristics of nanometric size, a high encapsulation of DTX and liposomes and particularly immunoliposomes containing DTX, which caused, as expected, a reduction in the viability of prostate cells, with high cellular internalization in EGFR overexpressing cells.

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