PURPOSE To evaluate the macular, retinal nerve fiber layer (RNFL) and choroidal thickness alterations by using spectral-domain optical coherence tomography (SD-OCT) in postmenopausal, pregnant and non-pregnant women. PATIENTS AND METHODS A comparative study included a total of 42 eyes (Right eye) of 42 healthy females in the period from march 2019 to September 2019 divided into 3 groups: a) Non pregnant women. b) Pregnant women.c) Postmenopausal women. Each subject underwent a comprehensive ophthalmologic examination. Following this detailed ophthalmologic examination, the Rs 3000 Nidek Japan OCT device was used for the assessment choroidal, macular and RNFL Thickness. RESULTS The mean age of non-pregnant females was 29.64 ±3.13, mean age of pregnant females was 28.93 ±3.89 and of postmenopausal women was 53.86 ± 1.75. There was no significant difference in all macular quadrants in the 3 study groups. Choroidal thickness was statistically significant thicker in healthy pregnant females (333.36 ±44.42) than in healthy non pregnant (326.93±31.50) and significantly thinner in healthy post-menopausal women (282.64±28.04) than healthy non pregnant females. There was no significant difference in RNFL thickness between the 3 study groups. CONCLUSION Oct has evolved over the past decade as one of the most important ancillary tests in ophthalmic practice. Pregnancy hormones may lead to an increase in fluid volume in many tissues of the body. There was no statistically significant difference in macular thickness and RNFL thickness between the 3 study groups. Choroidal thickness was statistically significant thicker in healthy pregnant than in healthy non pregnant and significant thinner in healthy post-menopausal women than healthy non pregnant.

Background: Keratoconus is a progressive bilateral disease characterized by corneal thinning. Cross linking is one of the most effective treatments of keratoconus and here we studied its objective and subjective effects. Aim of Study: This study aims to investigate differences in objective and subjective outcome of collagen corneal crosslinking of different keratoconus grades. Patient and Method: Twenty-four eyes of twenty-four patients with keratoconus were enrolled in this prospective study arranged into 2 groups according to k reading (Group I: Less than 48, Group II: 48-52); 12 eyes of patients in each group all the eyes underwent full ophthalmological clinical evaluation (Best Spectacle Corrected Visual Acuity (BSCVA) by log MAR and wave light Pentacam assessment to investigate Keratometry readings, Central Corneal Thickness (CCT), and Aberrations scan by Zernike analysis. Evaluations were done at baseline and 3 months' post CXL. Results: The BCVA insignificantly deteriorated in group I & II after 3 months follow-up by (0.016 ±0.04) p=0.166 and (0.016±0.08) p=0.503 respectively. The mean average K insignificantly decreased in group I & II by (0.216 ±0.63) p=0.261 and (0.250 ± 1.66) p=0.619 respectively. The mean central corneal thickness increased in group I by (11.00 ±31.97) p=0.258 while decreased in group II by (5.750± 16.75) p=0.259. The mean of total aberration of group I decreased by (0.033 ± 0.09) p=0.219, while in group II increased by (0.666 ±0.49) p=0.503. Conclusion: We found insignificant decrease in (BCVA, Average K,) in the two groups the mean CCT increased in group I and decreased in group II. The mean of total aberration decreased in group I while increased in group II.

Study design; Pilot randomized controlled study. Objective To compare success rates of endoscopic endonasal dacryocystorhinostomy and nasolacrimal duct intubation in congenital nasolacrimal duct obstruction (NLDO) in a trial to define the superiority of either technique. Patients & Methods Sixty-six eyes of 61 patients were diagnosed as having epiphora and mucopurulent discharge due to congenital NLDO. The patients were randomly divided into two groups; Group A; 33 eyes of 28 patients (treated by probing and silicone intubation only (NLDI)) and Group B; 33 eyes of 33 patients (treated by endoscopic endonasal dacryocystorhinostomy and silicone tube intubation (EDCR). All tubes were removed 6 months after the operation. Results The success rate, defined as complete resolution of clinical symptoms and signs after 6 months of follow up, was 72.7 % in Group A and 81.8% in Group B. Although the success rate was higher in Group B, yet the difference was shown to be statistically nonsignificant. Preoperative symptoms were assessed postoperatively after tube removal. Complete cure had a higher rate of occurrence in Group B than in Group A (27eyes (81.8%) versus 25 eyes of 22 patients (75.8%) respectively). Postoperative positive fluorescein dye disappearance test (FDDT) after tube removal was more in Group B than in Group A (27 eyes (81.8) versus 24 eyes of 21 patients (72.7 %) respectively). In Group A, silicone tubes had to be repositioned due to prolapse in 3 eyes of 3 patients (9.1%) and had to be removed early in 3 eyes of 3 patients (9.1%) due to failure of repositioning. In Group B, silicone tubes did not require early tube extraction before the date of removal in any of the patients. Intraoperative, there was only one case (3.0%) of fat prolapse during EDCR in Group B with no subsequent postoperative complications. Hemostasis did not represent a problem in any of the patients. Postoperative complications occurred more in Group B than Group A (21 eyes (63.6%) versus 13 eyes of 13 patients (39.4 %) respectively). Late complications occurred more in Group B than Group A (18 eyes (54.5%) versus 12 eyes of 12 patients (36.4%) respectively) in the form of persistent epiphora and tube prolapse. Conclusion The success rate of pediatric EDCR was higher than that of pediatric NLDI. The difference was statistically non-significant. Complications were comparable between the two groups. The study, being pilot in its comparative aspect between endoscopy and intubation, opens the horizon for further study on a larger group that probably will expand this difference.

Background: Many studies have used functional optical zone (FOZ) as a measure to compare different refractive laser treatment modalities. However, to our knowledge, no study has compared wavefrontoptimized (WFO) and wavefront-guided (WFG) laser in situ keratomileusis (LASIK) using FOZ. We compared the FOZ after WFO versus WFG LASIK in patients with myopia and myopic astigmatism.Methods: In this prospective comparative study, we included 100 myopic eyes of 50 patients with or without astigmatism. They were divided into two groups according to the platform used: WFO or WFG femtosecond LASIK. Using Holladay’s equivalent keratometry reading (EKR) report of Pentacam HR, FOZ was defined as a zone centered on the pupil center with a standard deviation (SD) of 0.5 D, around the mean EKR. The differences in FOZ between the two platforms were analyzed at 3 months postoperatively. Visual acuity, refractive error, corneal asphericity (Q-value), and root mean square of higher-order aberrations (RMS for HOAs) were evaluated and compared.Results: The mean ± SD of patient age was 26.64 ± 5.67 years. The preoperative characteristics of the two groups were comparable (all P > 0.05). The intended optical zone (IOZ) was 6 mm in both groups. The mean laser ablation depth was significantly greater in the WFG group (18 ?m per D) than in the WFO group (16 ?m per D) (P = 0.035). At 3 months postoperatively, the mean ± SD of FOZ diameter was 4.32 ± 0.94 mm (71.99 ± 15.68% of intended optical zone) in the WFO group and 4.16 ± 1.13 mm (69.33 ± 18.78% of intended optical zone) in the WFG group, with no significant difference between the two groups (P = 0.622). The change in corneal asphericity was greater in the WFG group than in the WFO group (P = 0.034). Postoperative mean corrected and uncorrected distance visual acuity, manifest refraction, and RMS for HOAs showed no significant difference between the two groups (all P > 0.05).Conclusions: We found that WFG LASIK resulted in greater ablation depth and change in corneal asphericity than WFO LASIK at 3 months postoperatively. However, there was no significant difference in FOZ diameter, refractive error, and RMS for HOAs between the two groups. Further research is needed to confirm these findings.