Long-Chain Hydrocarbons of Cannabis and Its Smoke A series of long-chain paraffins has been identified in Cannabis and its smoke by gas chromatography and mass spectrometry. The level of hydrocarbons was determined to be about half that found in tobacco and its smoke, although the effect of smoking on the paraffins in the Cannabis plant material was comparable to analogous studies of tobacco and its smoke.

In a study aimed toward developing new, selective antimuscarinic drugs with potential utility in the treatment of urinary incontinence associated with bladder muscle instability, a series of N-substituted 5-(aminomethyl)-3,3-diphenyl-2(3H)-furanones, conformationally-constrained lactone relatives of benactyzine, was prepared. The compounds were examined in several paradigms that measure muscarinic (M1, M2, and M3) receptor antagonist activity. Selected members of the series that displayed potency and/or selectivity in these tests were studied for their effects on urinary bladder contraction, mydriasis, and salivation in guinea pigs. These studies revealed that incorporation of the amino functionality into an imidazole or pyrazole ring resulted in some novel, potent, and selective antimuscarinic agents. Appropriate alkyl substitution of position 2 of the imidazole strikingly affected muscarinic, particularly M3, receptor activity and may reflect a complementary site of interaction. Some of the compounds selectively reduced bladder pressure in a cystometrogram (CMG) model without producing concomitant mydriatic and salivary effects. The separate and distinct action of several compounds of this series in these in vivo protocols suggests the possibility of subtypes of muscarinic receptors that may correspond to previously characterized molecular cloned subpopulations. In this article, structure-activity relationships for the series of substituted lactones are discussed. These studies led to the identification of (R)-[(2-isopropyl-1H-imidazol-1-yl)methyl]-4,5-dihydro-3,3-diphenyl-2(3H )- furanone (23) as a clinical candidate for treating urinary bladder dysfunction.

50 mL), and the ammonia was allowed to evaporate. To the residue were added ethyl ether (100 mL) and water (100 mL). The ether solution was extracted, dried, and evaporated, and phenyl methyl selenide was isolated (778 mg, 4.55 mmol, 90% yield) and then oxidized with Br2 in CCI4, giving a precipitate of phenyl methyl selenide dibromide: 1.115 g (3.3 mmol, 67% yield); after recrystallization from CCI4, mp 141-143 °C (lit.1 23 4mp 143-144 °C).Synthesis of o-Methylphenyl Methyl Selenide. o-Methylphenyl selenide ion was prepared as described above from 9.99 mmol of o-iodotoluene and 5.00 mmol of selenide ion with 4 h of irradiation, and then sodium metal was added in excess,

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