Despite the wide application of dynamic models in infectious disease epidemiology, the particular modeling of variability in the different model components is often subjective rather than the result of a thorough model selection process. This is in part because inference for a stochastic transmission model can be difficult since the likelihood is often intractable due to partial observability. In this work, we address the question of adequate inclusion of variability by demonstrating a systematic approach for model selection and parameter inference for dynamic epidemic models. For this, we perform inference for six partially observed Markov process models, which assume the same underlying transmission dynamics, but differ with respect to the amount of variability they allow for. The inference framework for the stochastic transmission models is provided by iterated filtering methods, which are readily implemented in the R package pomp by King and others (2016, Statistical inference for partially observed Markov processes via the R package pomp. Journal of Statistical Software69, 1-43). We illustrate our approach on German rotavirus surveillance data from 2001 to 2008, discuss practical difficulties of the methods used and calculate a model based estimate for the basic reproduction number $R_0$ using these data.

The normal tissue complication probability (NTCP) is a measure for the estimated side effects of a given radiation treatment schedule. Here we use a stochastic logistic birth-death process to define an organ-specific and patient-specific NTCP. We emphasize an asymptotic simplification which relates the NTCP to the solution of a logistic differential equation. This framework is based on simple modelling assumptions and it prepares a framework for the use of the NTCP model in clinical practice. As example, we consider side effects of prostate cancer brachytherapy such as increase in urinal frequency, urinal retention and acute rectal dysfunction.

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Infectious disease surveillance data often provides only partial information about the progression of the disease in the individual while disease transmission is often modelled using complex mathematical models for large populations, where variability only enters through a stochastic observation process. In this work it is shown that a rather simplistic, but truly stochastic transmission model, is competitive with respect to model fit when compared with more detailed deterministic transmission models and even preferable because the role of each parameter and its identifiability is clearly understood in the simpler model. The inference framework for the stochastic model is provided by iterated filtering methods which are readily implemented in the R package pomp. We illustrate our findings on German rotavirus surveillance data from 2001 to 2008 and calculate a model based estimate for the basic reproduction number R 0 using these data. *

Dynamic epidemic models have proven valuable for public health decision makers as they provide useful insights into the understanding and prevention of infectious diseases. However, inference for these types of models can be difficult because the disease spread is typically only partially observed e.g. in form of reported incidences in given time periods. This chapter discusses how to perform likelihoodbased inference for partially observed Markov epidemic models when it is relatively easy to generate samples from the Markov transmission model while the likelihood function is intractable. The first part of the chapter reviews the theoretical background of inference for partially observed Markov processes (POMP) via iterated filtering. In the second part of the chapter the performance of the method and associated practical difficulties are illustrated on two examples. In the first example a simulated outbreak data set consisting of the number of newly reported cases aggregated by week is fitted to a POMP where the underlying disease transmission model is assumed to be a simple Markovian SIR model. The second example illustrates possible model extensions such as seasonal forcing and over-dispersion in both, the transmission and observation model, which can be used, e.g., when analysing routinely collected rotavirus surveillance data. Both examples are implemented using the R-package pomp (King et al., 2016) and the code is made available online.