In fact, choosing a career and a university of high school pupils is very important. This study aims at identifying and measuring the factors affecting the decision of choosing a university of high school pupils in Quang Ngai province. The data of this study were collected from 340 answer sheets of grade 12 pupils of 5 high schools in Quang Ngai province in the 2019-2020 school year. By using the quantitative analysis methods, it has been shown that 5 factors are affecting the decision of choosing a university of pupils in Quang Ngai province, in the order of high importance to low including (1) University reputation, (2) Communication, (3) Learning conditions, (4) Factor belongs to the pupils, (5) Individuals.