We demonstrate that the measurement of CALCA gene transcripts in the bloodstream is feasible and may refine the management of patients with MTC and RET mutation-carrying relatives. We propose considering the application of this diagnostic tool as an alternative to the calcitonin-stimulation test.

a b s t r a c tObjective: To determine possible changes in serum concentrations of pro-and anti-inflammatory cytokines of eutrophic rats subjected to aerobic or resistance physical training. Methods: This study examined serum concentrations of TNF-␣, IFN-␥, IL-6, IL-10 and IL-1-␤ in rats that performed aerobic or resistance training for 16 weeks. Thirty-five Wistar rats (male adult) were divided into three groups: Control Group (CG), Aerobic Group (AG) and Resistance Group (RG). Rats were sacrificed 48 h after the final training session. Serum concentrations of cytokines were analysed by ELISA. Results: TNF-␣ levels were higher in the RG, followed by the AG and CG groups (p < 0.001). IFN-␥ and IL-10 levels were not significantly different between groups (p = 0.097 and p = 0.17, respectively). The levels of IL6 and IL1-␤ were higher in AG compared to RG and CG (p = 0.0004 and p = 0.003, respectively). In general, our results indicate a higher pro-inflammatory profile in AG and probably RG animals. Conclusion: Further studies are required in order to better clarify the effects of aerobic and resistance exercise training on pro-and anti-inflammatory cytokines. Additionally, future studies should address the metabolic and molecular pathways involved in these responses.

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