The volunteers in thece tests are enlisted US Army personnel. These tests are governed by the principles, policies, and rules for medical volunteers as established in AR 70-25. DIGESTThis report summarizes information on the physiological and toxicological effects of three riot control agents: CS, o-chlorobenzalmalononitrile; CN, chloroacetophenone; and DM, dimethyl aminochloroarsine. Included in the report is a review of the toxicity tests conducted on the old compounds CN and DM by various organizations from 1918 to the present, and on CS from 1958 to the present. Detailed results of experiments conducted by the Toxicology Department, Medical Research Laboratory, by various methods on animals of several species are given. Based on the animal experiments, estimates are given for lethal doses in man. Incapacitating doses P.e determined and reported on the basis of tolerance times of volunteers exposed to aerosols of th[e three compounds. Safety fac..ors, dern ed from ratios of estir, ated lethal doses to bncapacitatipg dimes, are reported for the three compour•ds, P CONTENTS

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