L'entreprise s'efforce aujourd'hui de transformer des actifs et des ressources en profit à travers des compétences spécifiques. Elle met ainsi en œuvre une nouvelle alchimie de la compétence. Apportant des définitions claires et opérationnelles de ce concept, souvent utilisé de façon confuse dans la littérature en gestion, l'auteur propose ici un modèle de la compétence articulé autour de trois dimensions qui relèvent de la connaissance (les savoirs), des pratiques (les savoir-faire) et des attitudes (le savoir être). Et il inclut dans ce modèle non seulement les processus de management mais aussi la structure organisationnelle, la décision stratégique et l'identité.

Drug-resistant epilepsy (DRE) occurs commonly in gliomas, possibly due to a shared mechanism of AMPA-activation involving both seizure activity and tumor growth. We tested the AMPA-receptor blocker perampanel (PER) in patients with DRE in low- and high-grade gliomas. Seizure response was defined as 50% drop in seizure frequency or as seizure-freedom. Cognitive function was examined by computerized test on cognitive speed (CTCS), which is sensitive to the type of cognitive dysfunction associated with epilepsy and use of anticonvulsants. Treatment policy included reduction of dose or discontinuation of one or more concurrent AEDs, once a seizure-free response was observed. Twelve patients were included patients, median age 41 years, 9 men versus 3 women and 6 months median duration of follow-up. An objective seizure response (75%) was observed in 9 (75%) out of 12 patients: 50%-seizure response in 3, seizure-freedom in 6, which is plainly more than seen with other types of DRE. Side-effects occurred in six patients. Cognitive function as examined by CTCS improved in six out of eight associated withlowering of concurrent AEDs. The final median dose of PER was 8 mg (varying between 2 and 12 mg). These results of an objective seizure response in 9 (75%) out of 12 patients treated by PER in DRE may be interpreted as a surrogate-marker of tumor response secondary to AMPA blockade, advancing confirmation by MR imaging. These results warrant further study of PER on tumor activity in gliomas.

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