. (1976). Annals of the Rheumatic Diseases, 35,[398][399][400][401][402][403][404][405][406]. Nervous system involvement in systemic lupus erythematosus. In a retrospective analysis of 80 patients with systemic lupus erythematosus (SLE) seen over a 10-year period, 41 (51 %) exhibited neurological manifestations. Nervous system involvement was characterized by a significantly greater involvement of black patients (P < 0 02), a higher incidence of renal failure after the first appearance of neurological features (P < 0 05), and a significantly worse 10-year survival rate (P < 0.05). Specific neurological investigations were generally unhelpful in diagnosis. (Trimble and others, 1974), were reviewed in detail. All clinical, laboratory, and treatment details were plotted sequentially for each patient. Convulsive or psychotic episodes occurring for the first time in association with uncontrolled hypertension (diastolic blood pressure > 120 mmHg) or severe uraemia (blood urea > 16-6 mmol/1; 100 mg/ml) were not considered primary manifestations of SLE and were excluded for the purpose of the study.

Author Contributions Statement: BCS and MAP designed the study. BCS obtained funding for this study. ANY and SEM were responsible for data collection and management. TG and REW provided statistical advice on study design and analyzed the data. MAP and BCS drafted the manuscript. All authors contributed substantially to manuscript revisions. BCS takes responsibility for the paper as a whole. BCS, TG, REW, ANY, and SEM had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. All authors approved the final report for submission.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

No abstract

No abstract