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ABSTKACT Signs, symptoms, and laboratory findings were presented to describe an early bout of multiple sclerosis (&IS). Data were derived from ITS.Army hospitalizations during the World War I1 period. For 293 men (group A), there had been previous bouts before the one for which they were hospitalized in the Army, whereas for 234 men (group B), this Army hospital bout was the onset bout. Median duration of this Army diagnostic bout was 2 months from onset to neurologic examination. Signs found at neurologic examination were classified into 8 functional systcms : pyramidal, cerebellar, brain stem, sensory, bowel and bladder, visual, cerebral, and miscellaneous; symptoms were categorized into 8 equivalent groups. Over-all dysfunction was graded according to the Disability Status Scale. There was a moderate degree of concordance between signs and symptoms of each type. In cvcry aspect save one, the group A and group B cases were indistinguishable; visual dysfunction was somewhat more prevalent in group A. Involvement at examination was most common in pyramidal (85 %), cerehellar (77 %), brain stem (73 %), and sensory (55 %); less common were bowel and bladder (23 %), visual ( 3 4 % ) , cerebral (mostly mood change) (21 yo), and miscellaneous signs (15 Yo). Each functional system tended to correlate with over-all disability in both frequency and severity of involvement. When symptoms were distributed by limbs affected, motor and coordination complaints showed a predilection for lower limbs and a tendency to symmetry, whereas sensory complaints were almost equally common in each body part. Cerebrospinal fluid findings were in accord with those of most series. ThereThis study is part of a program of medical follow-up studies organized by the NAS-NRC at the request of the Veterans Administration, the Department of Defense, and the Public Health Service. 2'

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